Table 5.
Strength of opinion of likelihood of missing studies | n | Estimated missing studies | Effect estimates* | |||
Mean (SD) | Median (IQR) | Range | LogHR (SElogHR) | HR (95% CI) | ||
‘Not likely’ | 1 | 0 | 0 | 0 | 0 (0.25)† | 1.0 (0.61 to 1.63)† |
‘Somewhat likely’ | 5 | 5.8 (2.4) | 5 (5–5) | 4–10 | −0.098 (0.074) | 0.91 (0.78 to 1.05) |
‘Quite likely’ | 8 | 17.8 (13.9) | 12.5 (10–20) | 7–50 | −0.144 (0.054) | 0.87 (0.78 to 0.96) |
‘Very/extremely likely’ | 4 | 37.5 | 40(25–50) | 20–50 | −0.078 (0.035) | 0.92 (0.86 to 0.99) |
All responders | 18 | 17.8 (16.5) | 10 (5–20) | 0–50 | −0.103 (0.066) | 0.90 (0.79 to 1.03) |
*Calculated using a simple weighted average of each responder.
†No studies were estimated from responder so for purposes of analysis and calculation of pooled estimate, one small and imprecise study was used.
RD, residual disease.