Table 1.

Inclusion and exclusion criteria

A. Inclusion criteria	B. Exclusion criteria
1. Aged 18 years or over and under 80 years;	1. Skin lesions near the acupuncture points;
2. Required mechanical ventilation>24 hours;	2. Coagulopathy (bleeding time>4 min, thrombocytes<50 000/μl;
3. Continuous intravenous administration of sedative and analgesic medications;	3. Hypohepatia with Childs-Pugh class B or C;
4. Willingness to provide informed consent prior to enrollment;	4. Second-degree or third-degree atrioventricular block;
5. Be able to comply with all follow-up evaluations (in investigator’s opinion).	5. Severe dementia;
	6. Psychiatric disorder;
	7. Neurological disease;
	8. Active seizures;
	9. Alcohol or drug abuse;
	10. Benzodiazepine dependency;
	11. Moribund state with the planned withdrawal of life support;
	12. Family or physician refusal;
	13. Pregnancy or lactation;
	14. Currently participated in any other investigational therapeutic or device trial.