Table 1.
Demographic and clinical characteristics of the study population
| Variable | YCU | OCU | EOCI | LOCI |
|---|---|---|---|---|
| n | 30 | 44 | 15 | 53 |
| Age (years) | 58.3 ± 5.5 | 72.8 ± 6.2b | 62.8 ± 6.0a | 76.4 ± 5.3ab |
| Age at onset (years) | n. a. | n. a. | 59.4 ± 5.6 | 73.6 ± 5.3b |
| Females,n(%) | 19 (63.3) | 26 (59.1) | 10 (66.7) | 33 (62.3) |
| Education (years) | 13.3 ± 3.9 | 11.6 ± 4.7 | 11.6 ± 5.0 | 10.5 ± 5.1 |
| MMSE | 28.9 ± 1.5 | 27.8 ± 1.8b | 21.5 ± 6.2a | 22.8 ± 4.2a |
| CDR-SB | 0.0 ± 0.0 | 0.0 ± 0.0 | 3.3 ± 2.3a | 2.9 ± 1.8a |
| APOEε4 carrier,n(%) | 5 (16.7) | 8 (18.2) | 10 (66.7)a | 26 (49.1)a |
| Amyloid positivity,n(%) | 1 (3.3) | 6 (13.6) | 15 (100)a | 53 (100)a |
| Follow-up interval (months) | 26.0 ± 3.6 | 25.1 ± 3.6 | 23.4 ± 1.5a | 23.0 ± 1.4a |
Data are presented as mean ± standard deviation. Significant between-group-differences are marked with “a” for YCU vs. EOCI and OCU vs. LOCI, and “b” for YCU vs. OCU and EOCI vs. LOCI
Abbreviations: YCU/OCU young and old cognitively unimpaired, EOCI/LOCI cognitively impaired due to early- and late-onset Alzheimer’s disease, MMSE mini-mental state examination, CDR-SB clinical dementia rating sum-of-boxes