Table 4.

Change from baseline in cardiovascular imaging endpoints*

	TAZPOWER Patients (n = 12)		Natural History Controls (n = 12)
Slope Model Analysis
	LV stroke volume (mL)
		Mean (SD) change from baseline; range	3.44 (5.26); − 1.7, 18.3	− 0.26 (2.66); − 4.9, 3.7
		P value	0.0407
	LV end-diastolic volume (mL)
		Mean (SD) change from baseline; range	4.89 (7.25); − 1.5, 24.7	0.91 (6.15); − 12.3, 11.2
		P value	0.1609
	LV end-systolic volume (mL)
		Mean (SD) change from baseline; range	1.46 (2.26); − 2.0, 6.4	1.17 (4.29); − 7.4, 9.1
		P value	0.8417
Mixed Model Analysis
	LV stroke volume (mL)
		LS mean change from baseline	1.92 − 4.80
		LS mean difference (95% CI), P value	6.72 (2.75, 10.69); P = 0.0020
	LV end-diastolic volume (mL)
		LS mean change from baseline	2.08 − 2.66
		LS mean difference (95% CI), P value	4.75 (− 2.72, 12.22); P = 0.2006
	LV end-systolic volume (mL)
		LS mean change from baseline	0.52 1.28
		LS mean difference (95% CI), P value	− 0.77 (− 7.13, 5.60); P = 0.8047

*Indexed to baseline body surface area

CI Confidence interval, LS Least squares, LV left ventricular, SD standard deviation