Table 2. Age-adjusted and age stratum-specific associations between underlying condition and hospitalisation, COVID-19 cases, EU/EEA^a, 2 June–13 December 2020.

Underlying condition	Age-adjusted model		Age-interaction model, stratum-specific aOR (95% CI)
	aOR (95% CI)	p valueb	< 20 years	20–29 years	30–39 years	40–49 years	50–59 years	60–69 years	70–79 years	≥ 80 years	Interaction p valueb
Asthma	1.83 (1.44–2.33)	< 0.0001	1.99 (0.87–4.56)	1.17 (0.48–2.87)	1.96 (1.08–3.55)	2.23 (1.36–3.65)	2.36 (1.51–3.70)	1.25 (0.72–2.19)	1.68 (0.83–3.38)	1.95 (0.75–5.07)	0.64
Cancer	2.01 (1.93–2.09)	< 0.0001	36.81 (26.02–52.08)	6.20 (3.93–9.77)	4.81 (3.62–6.39)	3.75 (3.15–4.47)	2.98 (2.69–3.31)	2.47 (2.28–2.68)	1.78 (1.66–1.90)	1.42 (1.33–1.53)	< 0.0001
Cardiac disorder	2.13 (2.07–2.18)	< 0.0001	5.47 (3.53–8.50)	4.37 (2.82–6.79)	4.74 (3.75–6.00)	3.76 (3.33–4.25)	3.12 (2.92–3.34)	2.12 (2.00–2.24)	1.86 (1.76–1.96)	1.85 (1.77–1.94)	< 0.0001
Diabetes	2.53 (2.45–2.61)	< 0.0001	8.75 (5.74–13.34)	6.46 (4.53–9.21)	6.17 (5.09–7.47)	5.59 (4.90–6.38)	4.82 (4.43–5.25)	2.97 (2.78–3.18)	2.20 (2.07–2.33)	1.68 (1.59–1.78)	< 0.0001
Immune deficiency disorder	3.58 (2.91–4.41)	< 0.0001	5.85 (1.80–19.05)	2.50 (0.78–7.98)	6.13 (3.40–11.05)	5.06 (3.07–8.36)	4.45 (3.08–6.43)	2.71 (1.70–4.32)	3.05 (1.81–5.16)	0.92 (0.38–2.24)	0.009
Hypertension	1.03 (0.88–1.20)	0.72	18.65 (6.44–54.07)	2.26 (0.30–16.73)	2.48 (1.15–5.35)	1.52 (0.94–2.45)	1.40 (1.05–1.87)	0.72 (0.54–0.97)	0.75 (0.55–1.03)	1.22 (0.87–1.71)	< 0.0001
Kidney disease	4.86 (4.37–5.40)	< 0.0001	9.95 (4.51–21.92)	9.57 (4.82–18.99)	9.75 (6.40–14.86)	8.76 (6.30–12.18)	7.61 (5.97–9.69)	4.98 (4.02–6.15)	3.54 (2.86–4.37)	2.97 (2.40–3.67)	< 0.0001
Liver disease	2.14 (1.82–2.52)	< 0.0001	10.64 (2.43–46.57)	4.69 (1.43–15.40)	3.18 (1.60–6.31)	4.53 (3.14–6.52)	2.21 (1.61–3.03)	2.43 (1.82–3.24)	1.28 (0.83–1.96)	0.66 (0.37–1.17)	< 0.0001
Lung disease	2.18 (2.05–2.31)	< 0.0001	1.60 (1.09–2.34)	1.94 (1.41–2.69)	2.63 (2.05–3.37)	2.70 (2.25–3.24)	2.58 (2.25–2.95)	2.40 (2.11–2.73)	2.00 (1.76–2.28)	1.74 (1.53–1.97)	< 0.0001
Neurological disorders	2.20 (2.02–2.41)	< 0.0001	8.34 (5.02–13.87)	5.82 (3.41–9.94)	5.21 (3.54–7.65)	4.92 (3.59–6.74)	4.01 (3.15–5.12)	3.23 (2.59–4.03)	1.72 (1.42–2.07)	1.46 (1.27–1.66)	< 0.0001
Obesity	1.83 (1.44–2.34)	< 0.0001	1.19 (0.16–8.65)	3.14 (1.66–5.92)	1.12 (0.52–2.41)	2.05 (1.29–3.25)	2.07 (1.42–3.03)	1.29 (0.77–2.16)	1.59 (0.86–2.95)	2.54 (1.21–5.34)	0.29
Any underlying condition (≥ 1)	2.35 (2.30–2.39)	< 0.0001	5.16 (4.42–6.02)	3.14 (2.73–3.62)	3.79 (3.44–4.18)	3.89 (3.64–4.16)	3.32 (3.17–3.48)	2.45 (2.35–2.55)	2.02 (1.94–2.09)	1.77 (1.71–1.83)	< 0.0001
Number of underlying conditions (1)c	2.29 (2.25–2.34)	< 0.0001	5.11 (4.35–6.00)	3.11 (2.68–3.62)	3.79 (3.42–4.19)	3.81 (3.55–4.09)	3.31 (3.16–3.47)	2.41 (2.31–2.51)	1.95 (1.88–2.03)	1.72 (1.66–1.78)	< 0.0001
Number of underlying conditions (2)c	2.61 (2.45–2.77)	< 0.0001	6.04 (3.49–10.43)	4.22 (2.78–6.41)	4.24 (3.13–5.75)	4.51 (3.68–5.53)	3.03 (2.61–3.52)	2.36 (2.10–2.66)	2.17 (1.93–2.43)	2.42 (2.15–2.73)	< 0.0001
Number of underlying conditions (≥ 3)c	4.58 (4.22–4.97)	< 0.0001	28.16 (10.42–76.05)	10.58 (4.10–27.31)	8.79 (4.83–15.99)	9.27 (6.64–12.95)	6.25 (5.07–7.70)	4.86 (4.14–5.71)	4.70 (4.06–5.44)	3.11 (2.70–3.58)	< 0.0001

aOR: adjusted odds ratio; CI: confidence interval; COVID-19: coronavirus disease; EU/EEA: European Union/European Economic Area; NA: not available as no outcome occurred within the age group.

^a Countries included in this analysis: Czechia, Finland, Ireland, Italy, Luxembourg, Malta, Norway, Poland and Slovakia.

^b p values based on likelihood ratio test.

^c Values are based on the same model. The reference group for all models was COVID-19 cases with no underlying conditions.