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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: FASEB J. 2022 Aug;36(8):e22428. doi: 10.1096/fj.202200369R

FIGURE 7. RetΔGlut1 mice have reduced lactate efflux and an altered metabolic profile.

FIGURE 7

A) Lactate efflux from isolated retinas incubated for 1 one hour in Ringer’s with 5mM glucose from control and RetΔGlut1 mice. Bars indicate average ± SEM for 4 retinas.

B) Partial Least-Squares Discriminant Analysis (PLS-DA) of Control and RetΔGlut1 samples from LC-MS data. Data points indicate results from 5 control and 3 RetΔGlut1.

C) Metabolomics analysis of significant metabolites changed in RetΔGlut1 retina samples. Raw data were normalized to the control average (hashed line), and statistical significance was obtained from T-tests after Pareto scaling. Bars indicate average (± SD) for 3-5 mice

D) Heat map of top 25 metabolites changed based on statistical significance or fold change between control and RetΔGlut1 retina samples, after Pareto scaling.