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. Author manuscript; available in PMC: 2022 Sep 2.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2020 Jul 30;29(10):2065–2069. doi: 10.1158/1055-9965.EPI-20-0472

Table 2.

Summary of SNPs within significant pathways with RCC associations observed in the discovery (P < 1.0 × 10−4) and replication (P<0.05) sets.

Discovery
 Replicationb
 Combinedc
SNP (Gene) Chr Positiona A/a OR (95% CI) P OR (95% CI) P OR (95% CI) P
rs12124078 (CASP9) 1 15869899 A/G 0.92 (0.88 to 0.96) 2.6 × 10−5 0.84 (0.77 to 0.92) 1.5 × 10−4 0.91 (0.87 to 0.94) 6.9 × 10−8
rs41324853 (CDKN2C) 1 51449575 T/C 1.10 (1.05 to 1.14) 2.0 × 10−5 1.15 (1.05 to 1.25) 2.3 × 10−3 1.11 (1.06 to 1.15) 2.4 × 10−7
rs2979488 (RBPMS) 8 30280630 A/G 1.10 (1.05 to 1.14) 1.3 × 10−5 1.13 (1.03 to 1.25) 8.8 × 10−3 1.11 (1.06 to 1.15) 4.4 × 10−7
rs61758464 (AKT1) 14 10525780 G /A 0.87 (0.82 to 0.93) 5.2 × 10−6 0.86 (0.76 to 0.98) 0.022 0.87 (0.83 to 0.92) 3.5 × 10−7
a

GRCh37.p13

b

Replication includes results from UK Biobank (903 cases, 451 361 controls) and GERA Cohort (317 cases, 50 511 controls) combined by meta-analysis using fixed effects model.

c

Summary results from meta-analysis using fixed effects model.