Table 3.
Frequency of vaccination reactions following SARS-CoV-2 vaccinations in people with multiple sclerosis in Germany and the United Kingdom.
| First vaccination |
Second vaccination |
pMc | q | |||||
|---|---|---|---|---|---|---|---|---|
| Germany | ||||||||
| N | 2346 |
1835 |
||||||
| N | % | CP CI | N | % | CP CI | |||
| Pain at injection area | 1094 | 46·6 | 44·5–48·6 | 887 | 48·3 | 46·0–50·6 | 0·55 | 0·55 |
| Fatigue | 771 | 32·9 | 30·9–34·8 | 731 | 39·8 | 37·5–42·1 | <0·0001 | <0·0001 |
| Headache | 517 | 22·0 | 20·3–23·7 | 509 | 27·7 | 25·6–29·8 | <0·0001 | <0·0001 |
| Asthenia | 441 | 18·8 | 17·2–20·4 | 490 | 26·7 | 24·6–28·7 | <0·0001 | <0·0001 |
| Melalgia/limb pain | 412 | 17·6 | 16·0–19·1 | 506 | 27·6 | 25·5–29·6 | <0·0001 | <0·0001 |
| Local reaction | 377 | 16·1 | 14·6–17·6 | 345 | 18·8 | 17·0–20·6 | <0·01 | <0·01 |
| Malaise | 347 | 14·8 | 13·3–16·1 | 411 | 22·4 | 20·5–24·3 | <0·0001 | <0·0001 |
| Muscular pain/myalgia | 344 | 14·7 | 13·2–16·1 | 346 | 18·9 | 17·0–20·0 | <0·0001 | <0·0001 |
| Flu-like symptom | 244 | 10·4 | 9·1–11·7 | 285 | 15·5 | 13·9–17·2 | <0·0001 | <0·0001 |
| Vertigo | 208 | 8·9 | 7·7–10·0 | 225 | 12·3 | 10·7–13·8 | <0·0001 | <0·0001 |
| Ague/undulant fever | 197 | 8·4 | 7·3–9·5 | 247 | 13·5 | 11·9–15·1 | <0·0001 | <0·0001 |
| Fever/pyrexia | 157 | 6·7 | 5·7–7·7 | 240 | 13·1 | 11·5–14·7 | <0·0001 | <0·0001 |
| Nausea | 128 | 5·5 | 4·5–6·4 | 132 | 7·2 | 6·1–8·4 | <0·01 | <0·01 |
| Swollen lymph nodes/lymphadenopathy | 101 | 4·3 | 3·5–5·2 | 129 | 7·0 | 5·9–8·2 | <0·0001 | <0·0001 |
| Palpitation/tachycardia | 80 | 3·4 | 2·7–4·2 | 75 | 4·1 | 3·2–5·0 | 0·03 | 0·04 |
| Rash/exanthema | 63 | 2·7 | 2·0–3·4 | 63 | 3·4 | 2·6–4·3 | 0·10 | 0·11 |
| Emesis/vomitus | 44 | 1·9 | 1·3–2·5 | 64 | 3·5 | 2·6–4·4 | <0·01 | <0·01 |
| Other | 154 | 6·6 | 5·5–7·6 | 139 | 7·6 | 6·4–8·8 | 0·17 | 0·19 |
| United Kingdom | pMc | q | ||||||
|---|---|---|---|---|---|---|---|---|
| N | 3796 |
683 |
||||||
| N | % | CP CI | N | % | CP CI | |||
| Fatigue | 1060 | 27·9 | 26·5–29·3 | 118 | 17·2 | 14·5–20·3 | <0·0001 | <0·0001 |
| Headache | 1007 | 26·5 | 25·1–27·9 | 73 | 10·6 | 8·4–13·2 | <0·0001 | <0·0001 |
| Pain (muscle/joint/other) | 986 | 26·0 | 24·5–27·4 | 83 | 12·1 | 9·7–14·8 | <0·0001 | <0·0001 |
| Redness | 737 | 19·4 | 18·1–20·7 | 97 | 14·2 | 11·6–17·0 | <0·0001 | <0·0001 |
| High temperature | 448 | 11·8 | 10·7–12·8 | 36 | 5·2 | 3·7–7·2 | <0·0001 | <0·0001 |
| Dizziness | 341 | 9·0 | 8·0–9·9 | 28 | 4·0 | 2·7–5·8 | <0·0001 | <0·0001 |
| Gastrointestinal complaints | 242 | 6·4 | 5·6–7·1 | 20 | 2·9 | 1·7–4·4 | <0·0001 | <0·0001 |
| Sensational complaints | 109 | 2·9 | 2·3–3·4 | 7 | 1·0 | 0·4–2·1 | <0·0001 | <0·0001 |
| Functional complaints | 55 | 1·4 | 1·0–1·8 | 3 | 0·4 | <0·1–1·3 | <0·0001 | <0·0001 |
| Rash | 40 | 1·1 | 0·8–1·4 | 2 | 0·3 | <0·1–1·0 | <0·0001 | <0·0001 |
| Anaphylaxis | 10 | 0·3 | 0·1–0·5 | 0 | 0·0 | n.a. | <0·0001 | <0·0001 |
| Other | 351 | 9·2 | 8·3–10·2 | 19 | 2·7 | 1·6–4·3 | <0·0001 | <0·0001 |
CP CI – 95% Clopper and Pearson confidence interval.
Mc – McNemar test.
N – number of patients.
p – p-value.
q – p-value adjusted according to false discovery rate.
SARS-CoV-2 – severe acute respiratory syndrome coronavirus 2.