Table 1.
Patients’ characteristics and histomorphometric dynamic indices of bone formation.
| Patients with T2DM (n=26) | |
|---|---|
| Αge (yrs) | 41.5 [38.0; 45.3] |
| Duration of T2DM (yrs) | 8.0 [6.0; 13.3] |
| Body mass index | 32.4 [28.9; 34.5] |
| Chronic complications (nb. of pat.) | 9 |
| Vertebral fractures1 (nb. of pat.) | 3 |
| HbA1c (%) | 7.6 [6.2; 9.6] |
| HbA1c <7% / >7% (nb. of pat.) | 10 / 16 |
| Medication | |
| Metformin (nb. of pat.) | 23 |
| SGLT2 (nb. of pat.) | 3 |
| Insulin (nb. of pat.) | 13 |
| Serum parameters | |
| FBG (mg/dL) | 148.0 [103.8; 235.8] |
| Calcium (mg/dL) | 9.2 [8.9; 9.5] |
| Phosphate | 3.6 [3.3; 4.0] |
| Intact PTH (pg/dL) | 44.9 [36.6; 60.8] |
| Pentosidine (pmol/mL) | 3596 [1501; 4541] |
| Histomorphometric parameters | |
| BV/TV (%) | 29.0 [23.0; 31.0]2 |
| MS/BS (%) | 1.4 [0.5; 4.0]3 |
| MAR (µm/day) | 0.61 [0.30; 0.71]3 |
| BFR/BS (µm3⋅µm-2⋅d-1) | 0.007 [0.002; 0.023]3 |
Data are median (25th, 75th percentiles).
diagnosis was based on lateral X-ray of the thoracic and lumbar spine (from T4 to L4) by the method described by Genant[44].
BV/TV of both subgroups with good (HbA1c<7%) or poor glycemic control (HbA1c>7%) are significantly higher compared to BV/TV of control group from previous publication[20].
No comparison of dynamic indices with control group available from previous publication[20], however dynamic indices do not differ to premenopausal OLS-control group of the current work (all p>0.05).
Abbreviations: HbA1c = glycated; hemoglobin; SGLT2 = type 2 sodium-glucose cotransporter inhibitors; FBG = fasting blood glucose; PTH = parathyroid hormone