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Figure 1. Clinical evaluation flowchart integrating risk factors, physical examination, evaluation of biomarkers and echocardiographic analysis. AF: atrial fibrillation;DM: diabetes mellitur; TR: tricuspid regurgitation; LAVI: left atrial volume index; LVMI: left ventricular mass index; RWT: left ventricular relative wall thickness; BNP: B-type natriuretic peptide; GLS: global longitudinal strain; PASP: pulmonary artery systolic pressure; HFpEF: heart failure with preserved ejection fraction. * Minor criterion should not be counted within the same domain.