TABLE 1.
Other promising natural products for treating SARS-CoV-2 infection in vitro.
| No. | Name | Structure | EC50 or IC50 (μM) | Strain | Refs |
|---|---|---|---|---|---|
| 1 | Aloin A |
|
15.68 | Vero E6 cells | Lewis et al. (2022) |
| 2 | Aloin B |
|
17.51 | Vero E6 cells | Lewis et al. (2022) |
| 3 | Andrographolide |
|
0.034 | Calu-3 cells | Sa-Ngiamsuntorn et al. (2021), Schulte et al. (2022) |
| 4 | Aspulvinone D |
|
10.3 | J774A.1 cells | Liang et al. (2022) |
| 5 | Aspulvinone M |
|
9.4 | J774A.1 cells | Liang et al. (2022) |
| 6 | Aspulvinone R |
|
7.7 | J774A.1 cells | Liang et al. (2022) |
| 7 | (+)-Aureol |
|
4.00 | Calu-3 cells | Chhetri et al. (2022) |
| 8 | Baicalein |
|
1.11 | E. coli BL21 cells | Wu et al., 2022a, Xiao et al. (2021) |
| 9 | Baicalin |
|
8.8 | Vero E6 cells | Ngwe Tun et al. (2022) |
| 10 | Bromophycolide A |
|
6.90 | Calu-3 cells | Chhetri et al. (2022) |
| 11 | Bufotalin |
|
0.072 | Vero E6 cells | Jin et al. (2021) |
| 12 | Cannabidiol |
|
1.24 | A549-ACE2 cells | Corpetti et al. (2021), Nguyen et al. (2022) |
| 13 | Cannabidiolic acid |
|
24 μg/mL | Vero E6 cells | van Breemen et al. (2022) |
| 14 | Cannabigerolic acid |
|
37 μg/mL | Vero E6 cells | van Breemen et al. (2022) |
| 15 | Chebulagic acid |
|
9.76 | Vero E6 cells | Du et al. (2021) |
| 16 | Cinobufagin |
|
0.072 | Vero E6 cells | Corpetti et al. (2021), Nguyen et al. (2022) |
| 17 | Cinobufotalin |
|
0.399 | Vero E6 cells | Jin et al. (2021) |
| 18 | Corilagin |
|
24.9 | HEK293 cells | Yang et al. (2021a) |
| 19 | Curcumin |
|
11.9 | Vero E6 cells | Bahun et al. (2022) |
| 20 | Cyclopeniol |
|
0.39 | RAW264.7 cells | Thissera et al. (2021) |
| 21 | Cyclopeptin |
|
0.40 | RAW264.7 cells | Thissera et al. (2021) |
| 22 | Dehydrocyclopeptin |
|
0.89 | RAW264.7 cells | Thissera et al. (2021) |
| 23 | Dieckol |
|
4.50 | Vero E6 cells | Yan et al. (2021) |
| 24 | Digitoxin |
|
0.059 | Vero E6 cells | Caohuy et al. (2021), Jin et al. (2021), Caohuy et al. (2022) |
| 25 | Dihydromyricetin |
|
1.14 | Vero E6 cells | Su et al. (2021), Xiao et al. (2021) |
| 26 | Dihydrotanshinone I |
|
8.14 | Vero E6 cells | Ma and Wang, (2022) |
| 27 | Dithymoquinone |
|
0.275 μg/mL | Vero E6 cells | Esharkawy et al. (2022) |
| 28 | Echinulin |
|
3.90 | Vero E6 cells | Alhadrami et al. (2022) |
| 29 | EGCG |
|
4.24 | Vero E6 cells | Chiou et al. (2022) |
| 30 | Ellagic acid |
|
11.8 | Vero E6 cells | Bahun et al. (2022) |
| 31 | (-)-Gallocatechin gallate |
|
5.77 | Vero E6 Cells | Xiao et al. (2021) |
| 32 | Glabridin |
|
2.5 | Vero E6 cells | Ngwe Tun et al. (2022) |
| 33 | Hesperidin |
|
51.5 | Vero E6 cells | Huang et al. (2022) |
| 34 | Isopetasin |
|
0.37 | Vero E6 cells | Urda et al. (2022) |
| 35 | Ivermectin |
|
0.55 | Vero E6 cells | Chable-Bessia et al. (2022) |
| 36 | Licoflavone C |
|
1.34 | Vero E6 cells | Corona et al. (2022) |
| 37 | LPC (14:0/0:0) |
|
0.92 | Vero E6 cells | Du et al. (2022) |
| 38 | LPC (16:0/0:0) |
|
1.48 | Vero E6 cells | Du et al. (2022) |
| 39 | LPC (16:0/18:1) |
|
0.14 | Vero E6 cells | Du et al. (2022) |
| 40 | Myricetin |
|
0.63 | Vero E6 cells | Kato et al. (2021), Su et al. (2021) |
| 41 | Neferine |
|
0.36 | HEK293/hACE2 cells | Yang et al. (2021b) |
| 42 | (+)-Neoechinulin A |
|
0.47 | Vero E6 cells | Alhadrami et al. (2022) |
| 43 | Neoechinulin B |
|
32.9 | Vero E6 cells | Nishiuchi et al. (2022) |
| 44 | Neopetasin |
|
1.26 | Vero E6 cells | Urda et al. (2022) |
| 45 | Oridonin |
|
2.16 | Vero E6 cells | Zhong et al. (2022) |
| 46 | Petasin |
|
10.79 | Vero E6 cells | Urda et al. (2022) |
| 47 | PGG |
|
3.66 | Vero E6 cells | Chiou et al. (2022) |
| 48 | Piniterpenoid A |
|
64.5 | Vero E6 cells | Li et al. (2021b) |
| 49 | Piniterpenoid C |
|
76.1 | Vero E6 cells | Li et al. (2021b) |
| 50 | Plitidepsin |
|
0.0043 | Vero E6 cells | Guisado-Vasco et al. (2022), Sachse et al. (2022) |
| 51 | Punicalagin |
|
6.19 | Vero E6 cells | Saadh et al. (2021) Suručić et al. (2021) |
| 52 | Resibufogenin |
|
1.606 | Vero E6 cells | Jin et al. (2021) |
| 53 | Salvianolic acid A |
|
2.49 | Vero E6 cells | Zhong et al. (2022) |
| 54 | Sangivamycin |
|
0.015 | Vero E6 cells | Bennett et al. (2022) |
| 55 | Scutellarein |
|
5.68 | E. coli BL21 cells | Wu et al. (2022c) |
| 56 | (+)-Shikonin |
|
4.38 | Vero E6 cells | Zhao et al. (2021), Ma et al. (2022) |
| 57 | Shikonin |
|
4.50 | Vero E6 cells | Cui and Jia (2021), Zhao et al. (2021) |
| 58 | Sulforaphane |
|
2.40 | Caco-2 cells | Ordonez et al. (2022) |
| 59 | Tanshinone IIA |
|
7.82 μg/mL | Vero E6 cells | Elebeedy et al. (2022) |
| 60 | Telocinobufagin |
|
0.142 | Vero E6 cells | Jin et al. (2021) |
| 61 | Thymohydroquinone |
|
0.023 μg/mL | Vero E6 cells | Esharkawy et al. (2022) |
| 62 | Tubercidin |
|
0.05 | Calu-3 cells | Schultz et al. (2022) |
| 63 | Ugonin J |
|
2.38 | Vero E6 Cells | Chiou et al. (2021) |
| 64 | 5,3′,4′-trihydroxyflavone |
|
8.22 | Vero E6 cells | Zhao et al. (2021) |
| 65 | 7-OH-Cannabidiol |
|
3.60 | A549-ACE2 cells | Nguyen et al. (2022) |