Table 3.
Risk factors for pneumonitis.
| Odds ratio | 95% CI | P-value | ||
|---|---|---|---|---|
| (Lower limit) | (Upper limit) | |||
| Age ≥ 70 years old | 0.476 | 0.0568 | 3.99 | .494 |
| Body mass Index ≥25 | 0.350 | 0.0295 | 4.15 | .406 |
| SpO2 | 0.642 | 0.346 | 1.20 | .114 |
| % Forced vital capacity | 1.04 | 0.957 | 1.13 | .384 |
| % Diffusing capacity for carbon monoxide | 0.967 | 0.886 | 1.05 | .425 |
| Indeterminate for usual interstitial pneumonia pattern1 | 0.667 | 0.0803 | 5.54 | .707 |
| Honeycomb lung on high-resolution computed tomography 2 | 12.0 | 0.936 | 154 | .056 |
| TP53 mutation 3 | 4.50 | 0.491 | 41.2 | .183 |
A univariate logistic regression analysis was performed to verify the risk of pneumonitis.
Regarding the radiological findings of pre-existing interstitial pneumonia as judged by the central review committee, 8 patients had indeterminate for usual interstitial pneumonia pattern.
Seven patients had honeycomb lung on high-resolution computed tomography.
TP53 mutations were detected in 6 patients and 11 were negative or unmeasured.