Table 2.
Univariate correlation with study cohort (multi-agent vs. single-agent vs. no chemotherapy for stage III low risk)
| Chemotherapy type | Parametric P-value a | |||||
|---|---|---|---|---|---|---|
| Covariate | Statistics | Level | No chemo, N = 11 221 | Single agent, N = 4028 | Multi-agent, N = 6236 | |
| Facility type | N (Col %) | Community cancer program | 1474 (13.14) | 476 (11.82) | 820 (13.15) | .029 |
| N (Col %) | Comprehensive community cancer program | 5530 (49.28) | 2016 (50.05) | 2982 (47.82) | ||
| N (Col %) | Academic/research program | 2534 (22.58) | 944 (23.44) | 1526 (24.47) | ||
| N (Col %) | Integrated network cancer program | 1683 (15) | 592 (14.7) | 908 (14.56) | ||
| Facility location | N (Col %) | Northeast | 2506 (22.33) | 968 (24.03) | 1302 (20.88) | <.001 |
| N (Col %) | South | 3797 (33.84) | 1379 (34.24) | 2170 (34.8) | ||
| N (Col %) | Midwest | 3112 (27.73) | 1023 (25.4) | 1958 (31.4) | ||
| N (Col %) | West | 1806 (16.09) | 658 (16.34) | 806 (12.92) | ||
| Sex | N (Col %) | Male | 4644 (41.39) | 1677 (41.63) | 2958 (47.43) | <.001 |
| N (Col %) | Female | 6577 (58.61) | 2351 (58.37) | 3278 (52.57) | ||
| Median income quartiles 2000 | N (Col %) | <$30 000 | 1511 (13.8) | 514 (13.09) | 803 (13.3) | .889 |
| N (Col %) | $30 000-$34 999 | 1990 (18.17) | 711 (18.11) | 1118 (18.51) | ||
| N (Col %) | $35 000-$45 999 | 3173 (28.98) | 1134 (28.88) | 1741 (28.83) | ||
| N (Col %) | ≥$46 000 | 4276 (39.05) | 1568 (39.93) | 2377 (39.36) | ||
| Median income quartiles 2008-2012 | N (Col %) | <$38 000 | 2052 (18.4) | 716 (17.87) | 1071 (17.29) | .356 |
| N (Col %) | $38 000-$47 999 | 2645 (23.72) | 935 (23.33) | 1503 (24.27) | ||
| N (Col %) | $48 000-$62 999 | 3095 (27.76) | 1086 (27.1) | 1716 (27.71) | ||
| N (Col %) | ≥$63 000 | 3359 (30.12) | 1270 (31.69) | 1903 (30.73) | ||
| Median income quartiles 2012-2016 | N (Col %) | <$40 227 | 2164 (19.58) | 777 (19.55) | 1101 (17.95) | .053 |
| N (Col %) | $40 227-50 353 | 2548 (23.06) | 864 (21.74) | 1442 (23.52) | ||
| N (Col %) | $50 354-63 332 | 2630 (23.8) | 939 (23.63) | 1502 (24.49) | ||
| N (Col %) | ≥$63 333 | 3708 (33.56) | 1394 (35.08) | 2087 (34.03) | ||
| Urban/rural 2003 | N (Col %) | Metro | 9176 (84.14) | 3230 (82.1) | 4899 (80.66) | <.001 |
| N (Col %) | Urban | 1221 (11.2) | 504 (12.81) | 800 (13.17) | ||
| N (Col %) | Rural | 508 (4.66) | 200 (5.08) | 375 (6.17) | ||
| Year of diagnosis | N (Col %) | 2004-2006 | 2567 (22.88) | 1008 (25.02) | 1120 (17.96) | <.001 |
| N (Col %) | 2007-2009 | 1990 (17.73) | 675 (16.76) | 1155 (18.52) | ||
| N (Col %) | 2010-2012 | 3368 (30.02) | 1021 (25.35) | 1983 (31.8) | ||
| N (Col %) | 2013-2015 | 3296 (29.37) | 1324 (32.87) | 1978 (31.72) | ||
| Grade | N (Col %) | Well differentiated, differentiated, and NOS | 814 (7.25) | 265 (6.58) | 461 (7.39) | .259 |
| N (Col %) | Moderately differentiated, moderately well differentiated, and intermediate differentiation | 7574 (67.5) | 2775 (68.89) | 4250 (68.15) | ||
| N (Col %) | Poorly differentiated | 2502 (22.3) | 856 (21.25) | 1356 (21.74) | ||
| N (Col %) | Undifferentiated, anaplastic | 331 (2.95) | 132 (3.28) | 169 (2.71) | ||
| Hispanic ethnicity | N (Col %) | No | 10163 (96.12) | 3653 (95.53) | 5637 (95.59) | .138 |
| N (Col %) | Yes | 410 (3.88) | 171 (4.47) | 260 (4.41) | ||
| Insurance type | N (Col %) | Not insured | 51 (0.46) | 15 (0.38) | 36 (0.58) | .003 |
| N (Col %) | Private insurance | 1018 (9.19) | 430 (10.78) | 658 (10.68) | ||
| N (Col %) | Government insurance | 10003 (90.35) | 3545 (88.85) | 5465 (88.73) | ||
| Surgical margins | N (Col %) | Negative | 10696 (95.86) | 3877 (96.76) | 5953 (96.28) | .033 |
| N (Col %) | Positive | 462 (4.14) | 130 (3.24) | 230 (3.72) | ||
| Charlson-Deyo scores | N (Col %) | 0 | 6433 (57.33) | 2549 (63.28) | 4137 (66.34) | <.001 |
| N (Col %) | 1 | 3055 (27.23) | 1008 (25.02) | 1582 (25.37) | ||
| N (Col %) | ≥2 | 1733 (15.44) | 471 (11.69) | 517 (8.29) | ||
| Tumor size | N (Col %) | ≤2 cm | 495 (4.5) | 202 (5.1) | 339 (5.55) | <.001 |
| N (Col %) | 2-4 cm | 3986 (36.24) | 1501 (37.88) | 2449 (40.1) | ||
| N (Col %) | >4 cm | 6517 (59.26) | 2260 (57.03) | 3319 (54.35) | ||
| Age at diagnosis | N | 11221 | 4028 | 6236 | <.001 | |
| Mean | 82.01 | 78.17 | 75.17 | |||
| Median | 83 | 78 | 74 | |||
| Min | 70 | 70 | 70 | |||
| Max | 90 | 90 | 90 | |||
| SD | 5.81 | 4.95 | 4.16 | |||
The parametric P-value is calculated by ANOVA for numerical covariates and χ2 test for categorical covariates.