Table 3.
Univariate correlation with study cohort (multi-agent vs. single-agent vs. no chemotherapy for stage III high-risk).
| Chemotherapy type | Parametric P-value a | |||||
|---|---|---|---|---|---|---|
| Covariate | Statistics | Level | No chemo N = 10 229 | Single agent N = 3306 | Multi-agent N = 6687 | |
| Facility type | N (Col %) | Community cancer program | 1379 (13.48) | 410 (12.4) | 899 (13.44) | <.001 |
| N (Col %) | Comprehensive Community cancer program | 5134 (50.19) | 1639 (49.58) | 3240 (48.45) | ||
| N (Col %) | Academic/research program | 2162 (21.14) | 787 (23.81) | 1640 (24.53) | ||
| N (Col %) | Integrated network cancer program | 1554 (15.19) | 470 (14.22) | 908 (13.58) | ||
| Facility location | N (Col %) | Northeast | 2411 (23.57) | 815 (24.65) | 1604 (23.99) | <.001 |
| N (Col %) | South | 3370 (32.95) | 1038 (31.4) | 2140 (32) | ||
| N (Col %) | Midwest | 2815 (27.52) | 906 (27.4) | 2001 (29.92) | ||
| N (Col %) | West | 1633 (15.96) | 547 (16.55) | 942 (14.09) | ||
| Sex | N (Col %) | Male | 3844 (37.58) | 1338 (40.47) | 3083 (46.1) | <.001 |
| N (Col %) | Female | 6385 (62.42) | 1968 (59.53) | 3604 (53.9) | ||
| Median income quartiles 2000 | N (Col %) | <$30 000 | 1319 (13.2) | 398 (12.36) | 802 (12.3) | .392 |
| N (Col %) | $30 000-$34 999 | 1774 (17.76) | 556 (17.27) | 1167 (17.9) | ||
| N (Col %) | $35 000-$45 999 | 2817 (28.2) | 960 (29.81) | 1850 (28.38) | ||
| N (Col %) | ≥$46 000 | 4079 (40.83) | 1306 (40.56) | 2699 (41.41) | ||
| Median income quartiles 2008-2012 | N (Col %) | <$38 000 | 1813 (17.81) | 539 (16.38) | 1058 (15.89) | .024 |
| N (Col %) | $38 000-$47 999 | 2388 (23.45) | 776 (23.59) | 1559 (23.42) | ||
| N (Col %) | $48 000-$62 999 | 2688 (26.4) | 923 (28.05) | 1862 (27.97) | ||
| N (Col %) | ≥$63 000 | 3293 (32.34) | 1052 (31.98) | 2179 (32.73) | ||
| Median income quartiles 2012-2016 | N (Col %) | <$40,227 | 1938 (19.19) | 584 (17.89) | 1128 (17.11) | .014 |
| N (Col %) | $40 227-50 353 | 2242 (22.2) | 735 (22.52) | 1456 (22.08) | ||
| N (Col %) | $50 354-63 332 | 2356 (23.33) | 816 (25) | 1623 (24.62) | ||
| N (Col %) | ≥$63 333 | 3563 (35.28) | 1129 (34.59) | 2386 (36.19) | ||
| Urban/rural 2003 | N (Col %) | Metro | 8392 (84.32) | 2621 (81.63) | 5277 (81.04) | <.001 |
| N (Col %) | Urban | 1075 (10.8) | 413 (12.86) | 840 (12.9) | ||
| N (Col %) | Rural | 485 (4.87) | 177 (5.51) | 395 (6.07) | ||
| Year of diagnosis | N (Col %) | 2004-2006 | 2057 (20.11) | 664 (20.08) | 1091 (16.32) | <.001 |
| N (Col %) | 2007-2009 | 1772 (17.32) | 497 (15.03) | 1127 (16.85) | ||
| N (Col %) | 2010-2012 | 3137 (30.67) | 931 (28.16) | 2174 (32.51) | ||
| N (Col %) | 2013-2015 | 3263 (31.9) | 1214 (36.72) | 2295 (34.32) | ||
| Grade | N (Col %) | Well differentiated, differentiated, and NOS | 475 (4.64) | 165 (4.99) | 320 (4.79) | <.001 |
| N (Col %) | Moderately differentiated, moderately well differentiated, and intermediate differentiation | 5315 (51.96) | 1849 (55.93) | 3745 (56) | ||
| N (Col %) | Poorly differentiated | 3839 (37.53) | 1107 (33.48) | 2264 (33.86) | ||
| N (Col %) | Undifferentiated, anaplastic | 600 (5.87) | 185 (5.6) | 358 (5.35) | ||
| Race | N (Col %) | White | 8980 (88.37) | 2903 (88.34) | 5852 (88.17) | .396 |
| N (Col %) | Black | 835 (8.22) | 257 (7.82) | 524 (7.9) | ||
| N (Col %) | Other | 347 (3.41) | 126 (3.83) | 261 (3.93) | ||
| Hispanic ethnicity | N (Col %) | No | 9248 (95.88) | 2970 (95.16) | 6034 (95.66) | .222 |
| N (Col %) | Yes | 397 (4.12) | 151 (4.84) | 274 (4.34) | ||
| Insurance type | N (Col %) | Not insured | 59 (0.59) | 24 (0.73) | 30 (0.45) | .029 |
| N (Col %) | Private insurance | 894 (8.87) | 327 (10) | 662 (10.03) | ||
| N (Col %) | Government insurance | 9124 (90.54) | 2920 (89.27) | 5906 (89.51) | ||
| Surgical margins | N (Col %) | Negative | 8382 (82.94) | 2888 (88.32) | 5778 (87.36) | <.001 |
| N (Col %) | Positive | 1724 (17.06) | 382 (11.68) | 836 (12.64) | ||
| Charlson-Deyo scores | N (Col %) | 0 | 6040 (59.05) | 2026 (61.28) | 4543 (67.94) | <.001 |
| N (Col %) | 1 | 2653 (25.94) | 904 (27.34) | 1572 (23.51) | ||
| N (Col %) | ≥2 | 1536 (15.02) | 376 (11.37) | 572 (8.55) | ||
| Tumor size | N (Col %) | ≤2 cm | 297 (2.96) | 93 (2.87) | 234 (3.58) | <.001 |
| N (Col %) | 2-4 cm | 2826 (28.2) | 1020 (31.45) | 2225 (34.05) | ||
| N (Col %) | >4 cm | 6899 (68.84) | 2130 (65.68) | 4076 (62.37) | ||
| Age at diagnosis | N | 10 229 | 3306 | 6687 | <.001 | |
| Mean | 82.19 | 79.17 | 75.65 | |||
| Median | 83 | 79 | 75 | |||
| Min | 70 | 70 | 70 | |||
| Max | 90 | 90 | 90 | |||
| SDv | 5.89 | 5.23 | 4.34 | |||
The parametric P-value is calculated by ANOVA for numerical covariates and χ2 test for categorical covariates.