Table 4.
Multivariable survival analysis stratified by stage and status in terms of chemotherapy for stage III low risk.
| Overall survival (years from diagnosis) | ||||
|---|---|---|---|---|
| Covariate | Level | N | Hazard ratio (95% CI) | HR P-value |
| Chemotherapy type | No chemo | 9867 | 2.49 (2.35-2.65) | <.001 |
| Single agent | 3590 | 1.17 (1.09-1.25) | <.001 | |
| Multiagent | 5462 | - | - | |
| Facility type | Community cancer program | 2464 | 1.10 (1.03-1.18) | .007 |
| Comprehensive Community cancer program | 9311 | 1.01 (0.96-1.07) | .674 | |
| Integrated network cancer program | 2729 | 1.11 (1.04-1.19) | .002 | |
| Academic/research program | 4415 | - | - | |
| Facility location | Northeast | 4116 | 0.97 (0.91-1.04) | .375 |
| South | 6607 | 1.05 (0.98-1.11) | .155 | |
| Midwest | 5224 | 1.04 (0.97-1.11) | .265 | |
| West | 2972 | NA | NA | |
| Sex | Male | 8155 | 1.26 (1.21-1.31) | <.001 |
| Female | 10 764 | NA | NA | |
| Median income quartiles 2000 | <$30 000 | 2575 | 1.09 (1.02-1.17) | .017 |
| $30 000-$34 999 | 3459 | 1.07 (1.01-1.14) | .024 | |
| $35 000-$45 999 | 5486 | 1.03 (0.98-1.09) | .206 | |
| ≥$46 000 | 7399 | NA | NA | |
| Urban/rural 2003 | Urban | 2235 | 1.01 (0.94-1.08) | .843 |
| Rural | 961 | 0.89 (0.81-0.98) | .020 | |
| Metro | 15 723 | NA | NA | |
| Grade | Moderately differentiated, moderately well differentiated, and intermediate differentiation | 12 862 | 1.01 (0.94-1.10) | .751 |
| Poorly differentiated | 4114 | 1.08 (0.99-1.18) | .084 | |
| Undifferentiated, anaplastic | 587 | 1.07 (0.93-1.23) | .355 | |
| Well differentiated, differentiated, and NOS | 1356 | NA | NA | |
| Race | Black | 1871 | 1.04 (0.97-1.12) | .279 |
| Other | 715 | 0.86 (0.76-0.97) | .014 | |
| White | 16 333 | NA | NA | |
| Hispanic ethnicity | Yes | 788 | 0.89 (0.80-1.00) | .046 |
| No | 18 131 | NA | NA | |
| Insurance type | Not insured | 93 | 1.31 (0.95-1.80) | .098 |
| Private insurance | 1852 | 0.96 (0.89-1.03) | .209 | |
| Government insurance | 16 974 | NA | NA | |
| Surgical margins | Positive | 714 | 1.55 (1.41-1.70) | <.001 |
| Negative | 18 205 | NA | NA | |
| Charlson-Deyo scores | 1 | 5040 | 1.20 (1.15-1.26) | <.001 |
| ≥2 | 2417 | 1.59 (1.51-1.69) | <.001 | |
| 0 | 11 462 | NA | NA | |
| Age at diagnosis | 18 919 | 1.04 (1.03-1.04) | <.001 | |