Fig. 1.

Systematic review. The method for systematic review of published studies to determine the dose response relationship (DRR) for the lethal H-ARS in young Rhesus macaques and canines exposed to TBI conducted without medical management. Published studies included those in the open, peer-reviewed literature and published government reports. A total of 3,077 hits were obtained via the search criteria. Studies accepted by the reviewers were divided into primary and secondary cohorts. The primary studies included those that determined the full DRR for mortality due to the H-ARS; secondary studies provided added values for dose-related mortality (equivalent to the primary studies in all criteria: radiation quality, absence of medical management, rhesus macaques, canines, etc.) but did not conduct a complete DRR for the H-ARS.