Table 5.

Characteristics of primary studies for canine models included in the systematic review.

Source/Authors		Samplesize	Radiation Source	Exposure Geometry	Dose Rate
Bond et al. 1956		115	9 Mev neutron; 250 kVp x-ray	Bilateral	20 rep min−1; 15.0 r min−1
Alpen et al. 1960		37	9 Mev neutron; 250 kVp x-ray	Bilateral	20 rep min−1; 15.0 r min−1
Earle et al. 1971		82	14.6 Mev; 1 Mvp x-ray	Bilateral	3 rads min−1; 35 R min−1
Ainsworth et al. 1965		457	1 Mev neutron;	Unilateral and bilateral	40 rad min−1
			1 Mvp x-ray;		110 cGy min−1
			1 Mev neutron	Unilateral	pulse rate
George et al. 1968	165		1 Mev neutron; 250 kVp x-ray	Rotational	16.8 rad min−1
MacVittie et al. 1984		51	1 Mev neutron; Co-60 gamma-ray	Bilateral, steady state	60 cGy min−1; 10.0 cGy min−1
MacVittie et al. 1991		144	1 Mev neutron; Co-60 gamma-ray	Bilateral, steady state	60 cGy min−1; 10.0 cGy min−1
Wang et al. 1991		128	1.33 Mev neutron	Unilateral	9.7–59.4 cGy min−1
a MacVittie and Jackson 2020		60	1 Mev neutron	Bilateral, steady state	60 cGy min−1

All primary studies were published in the open literature or in government publications. The primary studies provided complete data sets for establishing the dose response relationship (DRR) for mortality versus mixed gamma/neutron radiation dose. The radiation source, energy, gamma:neutron ratio, dose rate and exposure aspect varied.

^aRestrospective analysis of 1993 data.