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. 2022 Aug 19;13:975291. doi: 10.3389/fphar.2022.975291

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Copyright © 2022 Liu, Cao, Liu, Gao, Du, Wang, Cheng, Zhu, Jia, Pan, Zhang, Jiang, He, Xu, Zhang, An, Guo and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The therapeutic effect of T7-siYY1-exo in vitro. (A) LN229 cells were cultured in the presence of T7-siNC-exo/T7-siYY1-exo (5 μg/ml) and TMZ (50 μM)/IR (6Gy) for 2 days and apoptotic cells were visualized by caspase-3/7 apoptosis assay. The fluorescent was photographed under a confocal laser scanning microscope using Nikon NIS-Elements software (Nikon, Tokyo, Japan). Data in a are representative of three independent biological experiments. (B) LN229 cells administrated with T7-siNC-exo/T7-siYY1-exo (5 μg/ml) and TMZ (50 μM)/IR (6Gy) were subjected to FACS to detect apoptosis. p values are displayed as *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. (C) The effect of T7-siYY1-exo on LN229-IR-resistant and LN229-TMZ-resistant cells. The concentration of TMZ was 200 μM and the dose of IR was 12Gy. p values are displayed as *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.