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. 2022 Aug 19;13:975291. doi: 10.3389/fphar.2022.975291

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Copyright © 2022 Liu, Cao, Liu, Gao, Du, Wang, Cheng, Zhu, Jia, Pan, Zhang, Jiang, He, Xu, Zhang, An, Guo and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The systematic toxicity assessment of T7-siYY1-exo. (A) Histological analyses of liver, heart, kidney, lung and spleen sections stained with H&E of BALB/c mice post-intravenous injection of T7-siYY1-exo (200 μg) or Saline for 12 days (one dose every other day). (B) Clinical chemistry and hematology parameters for T7-siYY1-exo treated mice. p values are displayed as not significant (ns) for p > 0.05. (C) The expression level of serum inflammatory cytokines TNF-α, IL-1β and IL-6. (D) Body weight changes in T7-siYY1-exo treated mice.