Fig 7. Model for HG and inflammation-induced Acsl1 expression by CHREBP and NF-kappa B in macrophages.

A) We propose that in high glucose, CHREBP is depressed, and active nuclear CHREBP promotes the expression of Acsl1. B) Under inflammatory conditions that activate the NF-kappa B via dismissal of the inhibitory protein I kappa B (IkB) that prevents NF-kappa B nuclear transport, Acsl1 transcription is induced. C) Acsl1 expression can be further increased by high glucose and inflammatory stimuli via CHREBP and NF-kappa B.