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. 2022 Sep 2;13:5182. doi: 10.1038/s41467-022-32926-5

Fig. 6. 12H5 mimics the receptor-binding mode of H1 and H5.

Fig. 6

a–d Hydrogen bonds and salt bridges between 12H5 and 140-loop (b), 130-loop (d) and other sites (D190, H183 and Y98) (c). e–h Receptor mimicry of 12H5. e Hydrogen bond interactions between the receptor analog LSTc and the H1 RBS, as shown in the co-crystal structure (PDB code: 3UBE). The carbohydrate group of the LSTc Sia terminus stretches into a hydrophobic cavity enfolded by side chains of W153, L194, and V155. f Hydrogen bonding between the 12H5 LCDR1 tip and the V135-A137 stretch. Hydrogen bonds are shown as black dashed lines. F30aL of LCDR1 mimics the hydrophobic interaction with the RBS, resembling the carboxylate group of the LSTc Sia terminus. g Hydrogen bonds and hydrophobic interactions between the receptor analog LSTa and H5, as shown in the co-crystal structure (PDB code: 4K63). h 12H5: HAhrCA complex is aligning to the H5 structure. The probable hydrogen bonds are shown as yellow dashed lines.