Table 2.
Admission characteristics, interventions and outcome for phenotypes in the VIP2 study cohort
| Variable | Phenotype | p value | ||||||
|---|---|---|---|---|---|---|---|---|
| Non-geriatric | Geriatric | |||||||
| A-very low SOFA | B-respiratory failure | C-oldest old | D-moderate SOFA | E-renal failure | F-low SOFA | G-high SOFA | ||
| Number of patients | 159 | 94 | 27 | 57 | 101 | 46 | 26 | |
| Age—median (IQR) | 82 (81–84) | 83 (81–84) | 93 (90–95) | 83 (81–86) | 83 (81–84) | 84 (82–87) | 87 (83–90) | < 0.001 |
| Gender—number (% female) | 84 (53%) | 41 (44%) | 18 (67%) | 17 (30%) | 29 (29%) | 25 (54%) | 12 (46%) | < 0.001 |
| Residence—number (%) | ||||||||
| Own home | 140 (88%) | 79 (84%) | 17 (63%) | 48 (84%) | 86 (85%) | 32 (69%) | 9 (34%) | < 0.001 |
| Home with family or caregivers | 8 (5%) | 7 (7%) | 9 (33%) | 5 (8%) | 8 (7%) | 6 (13%) | 9 (34%) | < 0.001 |
| Nursing home or other hospital | 9 (5%) | 8 (8%) | 1 (3%) | 4 (7%) | 7 (6%) | 5 (10%) | 8 (30%) | 0.0017 |
| Other | 23 (1%) | 2 (1%) | 0 | 0 | 0 | 3 (6%) | 0 | 0.0051 |
| Admission reason—number (%) | ||||||||
| Respiratory/cardiovascular | 28 (17%) | 67 (71%) | 13 (48%) | 22 (38%) | 48 (37%) | 25 (54%) | 13 (50%) | < 0.001 |
| Sepsis | 4 (2%) | 6 (6%) | 1 (3%) | 9 (15%) | 18 (17%) | 3 (6%) | 10 (38%) | < 0.001 |
| 31 (19%) | 10 (10%) | 3 (11%) | 12 (21%) | 8 (7%) | 5 (10%) | 0 | 0.015 | |
| Emergency surgery Other | 96 (60%) | 11 (11%) | 10 (37%) | 14 (24%) | 37 (36%) | 13 (28%) | 3 (11%) | < 0.001 |
| SOFA score—median (IQR) sub-scores | 1 (0–2) | 4 (3–4) | 4 (2–4) | 6 (5–7) | 6 (5–8) | 3 (2–4) | 10 (8–13) | < 0.001 |
| Respiratory | 0 (0–1) | 2 (2–3) | 1 (0–2) | 1 (1–2) | 1 (0–2) | 1 (0–2) | 3 (2–3) | < 0.001 |
| Cardiovascular | 0 (0–0) | 0 (0–0) | 1 (0–1) | 1 (0–3) | 1 (0–3) | 0 (0–1) | 4 (3–4) | < 0.001 |
| Hepatic | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–1) | < 0.001 |
| Coagulation | 0 (0–0) | 0 (0–0) | 0 (0–0) | 2 (2–2) | 0 (0–0) | 0 (0–0) | 0 (0–1) | < 0.001 |
| Renal | 0 (0–0) | 0 (0–1) | 0 (0–1) | 1 (0–1) | 4 (3–4) | 0 (0–1) | 1 (1–2) | < 0.001 |
| Neurological | 0 (0–0) | 0 (0–1) | 0 (0–1) | 0 (0–0) | 0 (0–1) | 0 (0–1) | 3 (3–4) | < 0.001 |
| Geriatric features—median (IQR) | ||||||||
| CFS | 3 (2–3) | 4 (3–4) | 4 (3–5) | 3 (2–4) | 4 (3–4) | 6 (6–7) | 7 (7–7) | < 0.001 |
| Katz index | 6 (6–6) | 6 (6–6) | 6 (5–6) | 6 (6–6) | 6 (5–6) | 2 (1–3) | 1 (0–1) | < 0.001 |
| IQCODE | 3 (3–3.2) | 3.1 (3–3.2) | 3.3 (3.1–3.6) | 3 (3–3.2) | 3.1 (3–3.4) | 3.8 (3.3–4.1) | 4.5 (4.1–5) | < 0.001 |
| CPS | 7 (5–9) | 12 (11–14) | 9 (6–10) | 9 (7–12) | 11 (8–15) | 15 (13–19) | 11 (7–15) | < 0.001 |
| Interventions—number (%) | ||||||||
| Invasive ventilation | 24 (15%) | 34 (36%) | 7 (25%) | 16 (28%) | 23 (22%) | 8 (17%) | 23 (88%) | < 0.001 |
| Vasopressors | 26 (16%) | 24 (25%) | 9 (33%) | 24 (42%) | 47 (46%) | 13 (28%) | 25 (96%) | < 0.001 |
| Renal replacement therapy | 2 (1%) | 0 | 0 | 2 (3%) | 45 (45%) | 3 (6%) | 4 (15%) | < 0.001 |
| Length of stay (days)-median (IQR) | 2 (1–4) | 5 (2–8) | 2 (1–4) | 3 (2–6) | 5 (3–8) | 3 (2–5) | 4 (2–12) | < 0.001 |
| Outcome—number (%) | ||||||||
| Died in ICU | 3 (2%) | 3 (3%) | 1 (3%) | 4 (7%) | 8 (7%) | 4 (8%) | 13 (50%) | < 0.001 |
| Died within 30 days | 5 (3%) | 11 (11%) | 2 (7%) | 8 (14%) | 13 (12%) | 8 (17%) | 15 (57%) | < 0.001 |