Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 28;146(10):724–739. doi: 10.1161/CIRCULATIONAHA.121.057978

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

PMC Copyright notice

Figure 6. — Overexpression of the LIPC-E97G variant promotes peripheral cholesterol uptake. A and C, Decay of plasma ³H activity (glycerol tri[³H]oleate, hydrolysable; A) and plasma ¹⁴C activity ([¹⁴C]cholesteryl oleate, nonhydrolysable) levels (C) in APOE*3.Leiden.CETP mice overexpressing AAV-TBG-eGFP, AAV-TBG-LIPC, and AAV-TBG-LIPC-E97G injected with very-low-density lipoprotein (VLDL)–like particles. B and D, Decay of plasma ³H activity (glycerol tri[³H]oleate, hydrolysable; B) and plasma ¹⁴C activity ([¹⁴C]cholesteryl oleate, nonhydrolysable) levels (D) in APOE*3.Leiden.CETP mice¹⁴ overexpressing AAV-TBG-eGFP, AAV-TBG-LIPC, and AAV³-TBG-LIPC-E97G injected with radiolabeled murine VLDL. E, Liver ¹⁴C activity (cholesteryl ester, nonhydrolysable; left) and liver ³H activity (triolein, hydrolysable) levels (right) in APOE*3.Leiden.CETP mice overexpressing AAV-TBG-eGFP, AAV-TBG-LIPC, and AAV-TBG-LIPC-E97G injected with VLDL-like particles. F, Liver ¹⁴C activity (cholesteryl ester, nonhydrolysable; left) and liver ³H activity (triolein, hydrolysable levels (right) in APOE*3.Leiden.CETP mice overexpressing AAV-TBG-eGFP, AAV-TBG-LIPC, and AAV-TBG-LIPC-E97G injected with radiolabeled murine VLDL. G and I, Tissue ¹⁴C activity (cholesteryl ester, nonhydrolysable; G) and ³H activity (triolein, hydrolysable; I) levels in APOE*3.Leiden.CETP mice overexpressing AAV-TBG-eGFP, AAV-TBG-LIPC, and AAV-TBG-LIPC-E97G injected with VLDL-like particles. H and J, Tissue ¹⁴C activity (cholesteryl ester, nonhydrolysable; H) and ³H activity (triolein, hydrolysable; J) levels in APOE*3.Leiden.CETP mice overexpressing AAV-TBG-eGFP, AAV-TBG-LIPC, and AAV-TBG-LIPC-E97G injected with radiolabeled murine VLDL. n=8 per group. A 1-way ANOVA with Tukey correction for multiple comparisons was used for statistical analysis, with a P value cutoff at P<0.05. gWAT indicates gonadal white adipose tissue; iBAT, interscapular brown adipose tissue; sBAT, subscapular brown adipose tissue; and sWAT, subcutaneous white adipose tissue; and TGRL‚ triglyceride-rich lipoprotein. *P<0.05, human wild-type (LIPC-WT) vs LIPC-E97G. $P<0.05, enhanced green fluorescent protein (eGFP) vs LIPC-WT. #P<0.05, eGFP vs LIPC-E97G.