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. 2022 Aug 12;11:e77848. doi: 10.7554/eLife.77848

Figure 5. Enrichment of STAG2 and histone modifications at gene promoters.

(A) Heatmap of H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) signal enrichment in the promoter regions of genes in the indicated categories. (B) Density profile of H3K27ac ChIP-seq signal enrichment in the promoter regions of genes in the indicated categories as in (A). (C) Density profile of STAG2 ChIP-seq signal enrichment in the promoter regions of genes in the indicated categories as in (A). (D) Binding of STAG2 at the genomic loci of downregulated genes that encode cholesterol biosynthetic enzymes as revealed by ChIP-seq.

Figure 5.

Figure 5—figure supplement 1. STAG2 occupies the promoters of myelination genes.

Figure 5—figure supplement 1.

Tracks of STAG2 binding at the genomic loci of the downregulated myelination genes. Red arrows indicate the transcription direction.