Table 2.
rCBF in rats subjected to global cerebral ischemia induced by asphyxial cardiac arrest.
| Regions | CBF from HC* |
CBF from ACA rats after ROSC (% of HC)† | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 60 min | 76 min | 92 min | 108 min | 124 min | 140 min | 156 min | P (ANOVA) | ||
| Cortex | 159.40 | 63.78 ± 8.20 (40.01%)‡ |
69.29 ± 7.59 (43.47%) |
66.43 ± 6.47 (41.68%) |
71.30 ± 9.10 (44.73%) |
73.64 ± 13.64 (46.20%) |
67.34 ± 7.70 (42.24%) |
66.67 ± 9.07 (41.82%) |
0.968 |
| Hippocampus | 154.70 | 41.66 ± 5.55 (26.93%)‡ |
48.67 ± 5.52 (31.46%) |
56.51 ± 8.60 (36.53%) |
68.92 ± 6.25 (44.55%) |
81.68 ± 9.93 (52.80%) |
74.07 ± 6.57 (47.88%) |
71.61 ± 5.04 (46.29%) |
<0.0001 |
| Thalamus | 149.50 | 52.67 ± 6.38 (35.23%)‡ |
52.81 ± 5.64 (35.33%) |
52.73 ± 5.32 (35.27%) |
57.45 ± 5.78 (38.43%) |
60.19 ± 6.51 (40.26%) |
61.76 ± 7.51 (41.31%) |
66.07 ± 9.50 (44.19%) |
0.215 |
| Brainstem | 132.90 | 32.99 ± 10.08 (24.82%)‡ |
35.75 ± 9.22 (26.90%) |
40.38 ± 10.19 (30.38%) |
49.18 ± 10.51 (37.01%) |
48.94 ± 8.68 (36.83%) |
51.39 ± 10.71 (38.67%) |
42.19 ± 9.50 (31.74%) |
0.029 |
| Cerebellum | 153.40 | 78.13 ± 10.65 (50.93%) |
78.71 ± 7.83 (51.31%) |
76.08 ± 7.65 (49.60%) |
79.37 ± 9.40 (51.74%) |
82.98 ± 8.51 (54.10%) |
68.43 ± 8.20 (44.61%) |
64.83 ± 9.59 (42.26%)‡ |
0.410 |
| Regions | CBF from ACA rats before arousal† | ||||||||
| −96 min | −80 min | −64 min | −48 min | −32 min | −16 min | 0 min | P (ANOVA) | ||
| Cortex | 62.66 ± 5.10 | 62.45 ± 4.54 | 64.17 ± 5.60 | 74.45 ± 9.45 | 70.82 ± 13.99 | 61.32 ± 8.20 | 63.89 ± 10.47 | 0.727 | |
| Hippocampus | 54.69 ± 9.15 | 58.73 ± 7.71 | 73.11 ± 6.48 | 74.56 ± 9.37 | 67.91 ± 5.06 | 64.32 ± 5.73 | 71.61 ± 5.04 | 0.243 | |
| Thalamus | 52.23 ± 5.12 | 50.94 ± 4.88 | 61.08 ± 6.30 | 61.93 ± 9.16 | 58.54 ± 8.63 | 58.54 ± 8.63 | 58.74 ± 8.41 | 0.401 | |
| Brainstem | 38.11 ± 11.04 | 44.89 ± 11.56 | 44.91 ± 8.72 | 50.58 ± 8.34 | 47.18 ± 8.38 | 46.69 ± 11.34 | 37.78 ± 8.79 | 0.629 | |
| Cerebellum | 75.62 ± 7.47 | 78.77 ± 8.71 | 77.41 ± 7.14 | 74.48 ± 7.12 | 72.14 ± 10.49 | 63.87 ± 9.71 | 52.39 ± 8.01 | 0.122 | |
*
Data represents as mean (n=2) in unit ml/100g/min;
†
Data represents as mean ± SEM (n=10) in unit ml/100g/min;
‡
The lowest rCBF during the whole period. ACA, asphyxial cardiac arrest; CBF, cerebral blood flow; HC, healthy control; rCBF, regional cerebral blood flow; ROSC, return of spontaneous circulation.