Table 1.

Clinical features of monkeypox and smallpox.

Features	Monkeypox	Smallpox
Time
Incubation	7–14 days	7–14 days
Prodrome	Upto 4 days	Upto 4 days
Rash period	14–30 days	14–30 days
Symptoms
Fever	Yes	Yes
Headache	Yes	Yes
Tiredness	Yes	Yes
Lymphadenopathy	Yes	No
Rash distribution	Centrifugal	Centrifugal
Rash characteristics	Hard, first maculopapular, then vesicular and pustular, well-circumscribed	Hard, first maculopapular, then vesicular and pustular, well-circumscribed
Rash progression	Slow progression from 1 stage to the other; every stage lasting 2–3 days	Slow progression from 1 stage to the other; every stage lasting 2–3 days