Table 2.
Least square mean pain intensity difference of turmeric-boswellia formulation (TBF) from placebo for NRS (rest, movement and pressure).
| Time | NRS rest | NRS movement | NRS pressure | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TBF | Placebo | LSM Difference (P-T) | P * | TBF | Placebo | LSM Difference (P-T) | P * | TBF | Placebo | LSM Difference (P-T) | P * | |||||||||||||||||||
| LSM | SE (LSM) | 95% CI | LSM | SE (LSM) | 95% CI | LSM | SE (LSM) | 95% CI | LSM | SE (LSM) | 95% CI | LSM | SE (LSM) | 95% CI | LSM | SE (LSM) | 95% CI | |||||||||||||
| LL | UL | LL | UL | LL | UL | LL | UL | LL | UL | LL | UL | |||||||||||||||||||
| 0.5 | 7.3 | 0.11 | 6.9 | 7.6 | 7.5 | 0.11 | 7 | 7.8 | 0.2 | >.05 | 7.7 | 0.08 | 8 | 7.9 | 8.2 | 0.08 | 8 | 7.9 | 0.5 | .1557 | 7.7 | 0.08 | 8 | 7.9 | 8.2 | 0.08 | 8 | 8.4 | 0.5 | .1557 |
| 1 | 5.9 | 0.11 | 5.6 | 6.2 | 7.8 | 0.11 | 8 | 8.1 | 1.9 | .0037 | 6.2 | 0.08 | 6 | 6.4 | 8.1 | 0.08 | 6 | 6.4 | 1.9 | .0008 | 6.2 | 0.08 | 6 | 6.4 | 8.1 | 0.08 | 8 | 8.3 | 1.9 | .0008 |
| 1.5 | 4.8 | 0.11 | 4.5 | 5.1 | 7.7 | 0.11 | 7 | 8.1 | 2.9 | .0007 | 5.1 | 0.08 | 5 | 5.3 | 8.2 | 0.08 | 5 | 5.3 | 3.2 | .0001 | 5.1 | 0.08 | 5 | 5.3 | 8.2 | 0.08 | 8 | 8.5 | 3.2 | .0001 |
| 2 | 3.7 | 0.11 | 3.4 | 4 | 7.8 | 0.11 | 8 | 8.1 | 4.1 | .0002 | 3.6 | 0.08 | 3 | 3.8 | 8.2 | 0.08 | 3 | 3.8 | 4.6 | <.001 | 3.6 | 0.08 | 3 | 3.8 | 8.2 | 0.08 | 8 | 8.4 | 4.6 | <.001 |
| 2.5 | 2.7 | 0.11 | 2.4 | 3 | 7.8 | 0.11 | 7 | 8.1 | 5 | .0001 | 2.7 | 0.08 | 2 | 2.9 | 8.2 | 0.08 | 2 | 2.9 | 5.5 | <.001 | 2.7 | 0.08 | 2 | 2.9 | 8.2 | 0.08 | 8 | 8.4 | 5.5 | <.001 |
| 3 | 1.9 | 0.11 | 1.5 | 2.2 | 7.8 | 0.11 | 8 | 8.1 | 5.9 | <.001 | 1.7 | 0.08 | 2 | 2 | 8.1 | 0.08 | 2 | 2 | 6.4 | <.001 | 1.7 | 0.08 | 2 | 2 | 8.1 | 0.08 | 8 | 8.3 | 6.4 | <.001 |
| 3.5 | 1.4 | 0.11 | 1.1 | 1.7 | 7.8 | 0.11 | 7 | 8.1 | 6.3 | <.001 | 1.3 | 0.08 | 1 | 1.6 | 8.2 | 0.08 | 1 | 1.6 | 6.8 | <.001 | 1.3 | 0.08 | 1 | 1.6 | 8.2 | 0.08 | 8 | 8.4 | 6.8 | <.001 |
| 4 | 1.1 | 0.11 | 0.8 | 1.4 | 7.8 | 0.11 | 8 | 8.1 | 6.7 | <.001 | 1 | 0.08 | 1 | 1.2 | 8.1 | 0.08 | 1 | 1.2 | 7.1 | <.001 | 1 | 0.08 | 1 | 1.2 | 8.1 | 0.08 | 8 | 8.3 | 7.1 | <.001 |
| 4.5 | 0.8 | 0.11 | 0.5 | 1.1 | 7.8 | 0.11 | 7 | 8.1 | 6.9 | <.001 | 0.9 | 0.08 | 1 | 1.1 | 8.1 | 0.08 | 1 | 1.1 | 7.2 | <.001 | 0.9 | 0.08 | 1 | 1.1 | 8.1 | 0.08 | 8 | 8.4 | 7.2 | <.001 |
| 5 | 0.5 | 0.11 | 0.2 | 0.8 | 7.8 | 0.11 | 7 | 8.1 | 7.2 | <.001 | 0.6 | 0.08 | 0 | 0.8 | 8.1 | 0.08 | 0 | 0.8 | 7.5 | <.001 | 0.6 | 0.08 | 0 | 0.8 | 8.1 | 0.08 | 8 | 8.3 | 7.5 | <.001 |
| 5.5 | 0.3 | 0.11 | 0 | 0.6 | 7.8 | 0.11 | 8 | 8.1 | 7.5 | <.001 | 0.5 | 0.08 | 0 | 0.7 | 8.2 | 0.08 | 0 | 0.7 | 7.7 | <.001 | 0.5 | 0.08 | 0 | 0.7 | 8.2 | 0.08 | 8 | 8.4 | 7.7 | <.001 |
| 6 | 0.2 | 0.11 | -0 | 0.5 | 7.8 | 0.11 | 8 | 8.1 | 7.6 | <.001 | 0.2 | 0.08 | 0 | 0.5 | 8.2 | 0.08 | 0 | 0.5 | 8 | <.001 | 0.2 | 0.08 | 0 | 0.5 | 8.2 | 0.08 | 8 | 8.4 | 8 | <.001 |
LSM = least square mean; NRS = numerical rating scale; P = placebo; T = treatment; TBF = turmeric-boswellia formulation.
*
P-value, 2-sided Bonferroni.