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Monosialotetrahexosyl ganglioside-incorporated reconstituted high-density lipoprotein (GM1-rHDL) possesses antibody-like high binding affinity to Aβ, facilitates Aβ degradation by microglia and Aβ efflux across the blood-brain barrier (BBB), and simultaneously allows the efficient loading of neuroprotective agents, serving as a nanoparticulate drug delivery system for the combination therapy of AD [155].
