Fig. 3.

Kinetics of IgM(N), IgG(N) and IgG(S) levels since diagnosis in the total sample and stratified by gender. A, C and E show the LOESS regression models, connecting datapoints belonging to the same participants. B, D and F show the estimated non-linear mixed-effect (NLME) model curves. Each point corresponds to the mean value at each time point. The bars correspond to the standard deviation. The dashed and the solid horizontal lines represent the uncertainty and positivity thresholds, respectively