Skip to main content
. 2022 Jul 29;41(36):4231–4243. doi: 10.1038/s41388-022-02413-8

Fig. 7. Impeding the urea cycle/polyamine synthesis suppresses LVBU-high CRC growth in PDXs.

Fig. 7

a Treatment schedule of ODC1 inhibitor DFMO is indicated. DFMO (Vehicle) was i.p. injected every day until the end of the experiments. b LVBU and BCL6 RNA fluorescence in situ hybridization (FISH) staining in indicated PDX tumor sections. c Tumor growth curve of immunocompromised mice engrafted with indicated CRC PDXs that express high or low LVBU. Representative xenograft images and statistical analysis of tumor volume and weight with or without DFMO treatment are shown (N = 4 or 5 independent tumors, *p < 0.05; ***p < 0.001). d IHC staining for Ki-67, OTC, ARG1, ODC1 and fluorescence TUNEL staining on indicated CRC PDX tumor sections. The staining intensity was quantitated by Image J and presented as bar graphs (N = 3 independent experiments, *p < 0.05; ***p < 0.001).