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. 2022 Jul 29;41(36):4231–4243. doi: 10.1038/s41388-022-02413-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Upon the induction of LVBU by hypoxia, BCL6 is no longer vulnerable to miR-10a/34c-mediated degradation due to LVBU’s sponging effect and is therefore stabilized, which in turn attenuates the transcriptional repressing activity of p53 to allow the expression of ARG1, CPS1, OTC, and ODC1, thereby promoting tumorigenesis via regulating UC/polyamine synthesis.