Extended Data Fig. 3. Transcription factors and super enhancers in the KCNJ15 locus.
(a) Predicted gene regulatory interactions in granulocytes between differentially expressed TFs associated with DA peaks belonging to enriched GO terms in Fig. 5a. Blue boxes: genes. Orange ovals: proteins. Orange arrows: translation. Green arrows: autoregulatory loops. Red arrows: cross-regulation of paralogous TFs. Black arrows: cross-regulation of other TFs. (b) KCNJ15 locus: green and red ticks indicate DA peaks up-regulated in response to infection in granulocytes and monocytes respectively. Orange and blue boxes indicate the corresponding super-enhancer regions. Blue lines: predicted transcription factor binding sites for master transcription factors in DA peaks.