Table 3.
The removal rate by dialysis of unchanged upacicalcet and hemodialysis clearance after single and multiple doses of upacicalcet
| A is the removal rate by dialysis of unchanged upacicalcet and hemodialysis clearance after single dose of upacicalcet | ||||
|---|---|---|---|---|
| Step | Group | N | Removal rate by dialysis of unchanged upacicalcet (%) | Hemodialysis clearance (mL/min) |
| Step 1 | 0.025 mg | 4 | 100.00 ± 0.00 | – |
| Step 2 | 0.05 mg | 4 | 94.53 ± 10.95 | – |
| Step 3 | 0.1 mg | 4 | 81.00 ± 14.05 | 61.40 ± 60.25* |
| Step 4 | 0.2 mg | 4 | 78.40 ± 4.47 | 168.25 ± 2.50 |
| Step 5 | 0.4 mg | 4 | 80.40 ± 7.34 | 125.83 ± 39.55** |
| Step 6 | 0.6 mg | 4 | 81.35 ± 3.76 | 183.00 ± 9.90* |
| Step 7 | 0.8 mg | 5 | 83.66 ± 13.37 | 156.00 ± 12.25*** |
| B is the removal rate by dialysis of unchanged upacicalcet after multiple dose of upacicalcet | |||||
|---|---|---|---|---|---|
| Step | Group | N | Removal rate by dialysis of unchanged upacicalcet (%) | ||
| Step 1 | 0.05 mg | 3 | 79.27 ± 3.39 | ||
| Step 2 | 0.1 mg | 6 | 80.68 ± 7.68 | ||
| Step 3 | 0.2 mg | 4 | 86.98 ± 4.97 | ||
The removal rate by dialysis of unchanged upacicalcet in plasma was calculated from the following equation. Removal rate by dialysis (%) = (CBD – CAD)/CBD×100
Hemodialysis clearance was calculated from the following equation. CL (mL/min f0) = (CBI − CBO)/CBI × 200*
AD after dialysis, BD before dialysis, C concentration, BI blood in, BO blood out, C concentration
*Blood flow
Only removal rate by dialysis of unchanged upacicalcet was calculated in multiple-dose study.
Mean ± SD, *n=2, **n=3, ***n=4