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. 2022 Jun 14;61(9):1251–1270. doi: 10.1007/s40262-022-01132-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Fat-free mass index (a) and fat mass index (b) relative to BMI. The blue, red and black lines represent the predicted mean of virtual male individuals, virtual female individuals and from all virtual subjects, respectively. The area within the two dashed lines represents the 99% normal range. Asterisks represent observed data from the development and circles represent observed data from the independent verification dataset. Male and female data points are represented in light blue and pink, respectively. BMI body mass index