Table 2.
Top 10 pathways from KEGG, BioPlanet, Reactome, WikiPathways databases and their corresponding p-values and genes for AR-DEGs.
| Databases | Pathways | p-value | Genes |
|---|---|---|---|
| KEGG | Longevity regulating pathway | 2.12E−04 | ADIPOQ;EIF4EBP1;PRKAB1 |
| AMPK signaling pathway | 3.42E−04 | ADIPOQ;EIF4EBP1;PRKAB1 | |
| Apelin signaling pathway | 5.04E−04 | GABARAPL1;AGTR1;PRKAB1 | |
| Insulin signaling pathway | 5.04E−04 | BAD;EIF4EBP1;PRKAB1 | |
| cGMP-PKG signaling pathway | 8.96E−04 | BAD;AGTR1;VDAC1 | |
| Calcium signaling pathway | 0.002531 | AGTR1;CXCR4;VDAC1 | |
| Acute myeloid leukemia | 0.002673 | BAD;EIF4EBP1 | |
| Mitophagy | 0.002752 | GABARAPL1;TFEB | |
| Adipocytokine signaling pathway | 0.002832 | ADIPOQ;PRKAB1 | |
| Endocytosis | 0.002905 | CXCR4;CHMP4B;AP2M1 | |
| BioPlanet | AMPK signaling | 6.34E−05 | ADIPOQ;EIF4EBP1;PRKAB1 |
| Mitochondrial pathway of apoptosis: BH3-only Bcl-2 family | 1.83E−04 | CAPN12;BAD;VDAC1 | |
| Phosphoinositides and their downstream targets | 3.73E−04 | BAD;AP2M1 | |
| PKB-mediated events | 4.70E−04 | EIF4EBP1;PRKAB1 | |
| TOR signaling | 6.94E−04 | EIF4EBP1;PRKAB1 | |
| Endocytosis | 0.001527 | CXCR4;CHMP4B;AP2M1 | |
| Calcineurin-dependent NFAT signaling role in lymphocytes | 0.00181 | RCAN1;BAD | |
| Acute myeloid leukemia | 0.001943 | BAD;EIF4EBP1 | |
| ERK1/ERK2 MAPK pathway | 0.002518 | BAD;EIF4EBP1 | |
| Adipocytokine signaling pathway | 0.002673 | ADIPOQ;PRKAB1 | |
| Reactome | Macroautophagy Homo sapiens R-HSA-1632852 | 6.07E−05 | GABARAPL1;CHMP4B;PRKAB1 |
| Cellular responses to stress Homo sapiens R-HSA-2262752 | 7.49E−04 | GABARAPL1;HSF1;CHMP4B;PRKAB1 | |
| mTOR signalling Homo sapiens R-HSA-165159 | 9.13E−04 | EIF4EBP1;PRKAB1 | |
| PKB-mediated events Homo sapiens R-HSA-109703 | 9.61E−04 | EIF4EBP1;PRKAB1 | |
| Disease Homo sapiens R-HSA-1643685 | 0.001206 | BAD;CXCR4;CHMP4B;HSPG2;AP2M1 | |
| HIV Infection Homo sapiens R-HSA-162906 | 0.002028 | CXCR4;CHMP4B;AP2M1 | |
| PI3K Cascade Homo sapiens R-HSA-109704 | 0.003693 | EIF4EBP1;PRKAB1 | |
| Degradation of the extracellular matrix Homo sapiens R-HSA-1474228 | 0.006547 | CAPN12;HSPG2 | |
| Infectious disease Homo sapiens R-HSA-5663205 | 0.007144 | CXCR4;CHMP4B;AP2M1 | |
| Nef Mediated CD8 Down-regulation Homo sapiens R-HSA-182218 | 0.008023 | AP2M1 | |
| WikiPathway | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities WP3844 | 5.28E−06 | BAD;TFEB;EIF4EBP1 |
| Leptin and adiponectin WP3934 | 5.66E−05 | ADIPOQ;PRKAB1 | |
| AMP-activated protein kinase (AMPK) signaling WP1403 | 6.62E−05 | ADIPOQ;EIF4EBP1;PRKAB1 | |
| The influence of laminopathies on Wnt signaling WP4844 | 7.36E−04 | ADIPOQ;DICER1 | |
| Target Of Rapamycin (TOR) Signaling WP1471 | 7.78E−04 | EIF4EBP1;PRKAB1 | |
| Synaptic signaling pathways associated with autism spectrum disorder WP4539 | 0.001499 | EIF4EBP1;PRKAB1 | |
| RAC1/PAK1/p38/MMP2 Pathway WP3303 | 0.002752 | BAD;EIF4EBP1 | |
| Peptide GPCRs WP24 | 0.003249 | AGTR1;CXCR4 | |
| Leptin signaling pathway WP2034 | 0.003424 | BAD;EIF4EBP1 | |
| IL-18 signaling pathway WP4754 | 0.003602 | BAD;ADIPOQ;ZC3H12A |