Table 2.
Effects of KM model and drug treatments on brain activity, manic behavior assessed with the OFA, and cognitive function assessed with the NOR task.
| Group | dlPFC Ca2+ activity, ∆F/F0 | OFA pathlength, m | NOR, novel time % |
|---|---|---|---|
| Naive | 125.70 ± 1.85 | 27.03 ± 1.22 | 82.16 ± 1.78 |
| Manic | |||
| Untreated | 187.04 ± 5.20 | 43.08 ± 1.47 | 50.45 ± 1.15 |
| Li | 150.22 ± 2.19 | 32.84 ± 1.30 | 67.99 ± 1.10 |
| VPA | 121.45 ± 1.37 | 26.33 ± 1.22 | 43.48 ± 1.74 |
KM ketamine-induced mania, OFA open field activity, NOR novel object recognition, dlPFC dorsolateral prefrontal cortex, Li lithium, VPA valproate.