Table 2.

Results of the uni- and multivariable Cox regression analysis on progression-free survival and overall survival for patient with diffuse large B-cell lymphoma treated with R-CEOP versus R-CHOP.

Covariate	Univariable						Multivariable
	PFS			OS			PFS			OS
	HR	95% CI	P-value^b	HR	95% CI	P-value^b	HR^a	95% CI	P-value^b	HR^a	95% CI	P-value^b
R-CEOP
No	1	Reference		1	Reference		1	Reference		1	Reference
Yes	1.43	1.02–2.00	0.04	1.43	1.00–2.03	0.05	1.55	1.11–2.17	0.01	1.58	1.11–2.25	0.01
Sex
Female	1	Reference		1	Reference		1	Reference		1	Reference
Male	1.54	1.12–2.10	<0.01	1.48	1.07–2.06	0.02	1.50	1.09–2.06	0.01	1.40	1.00–1.95	0.05
Age
18–60	1	Reference		1	Reference
≥61	1.94	1.22–3.09	<0.01	2.30	1.37–3.86	<0.01
Ann arbor stage
I, II	1	Reference		1	Reference		1	Reference		1	Reference
III, IV	2.17	1.51–3.12	<0.01	2.13	1.45–3.12	<0.01	2.03	1.25–3.30	<0.01	1.87	1.11–3.16	0.02
IPI score
0–2	1	Reference		1	Reference		1	Reference		1	Reference
3–5	2.12	1.57–2.86	<0.01	2.28	1.65–3.14	<0.01	1.79	1.20–2.67	<0.01	2.16	1.39–3.36	0.01
Number of cycles
≥6 cycles	1	Reference		1	Reference		1	Reference		1	Reference
<6 cycles	2.36	1.76–3.17	<0.01	2.95	2.16–4.01	<0.01	3.30	2.42–4.49	<0.01	4.25	3.08–5.87	<0.01

Abbreviations: IPI International Prognostic Index, CI confidence interval.

^aEach covariate is simultaneously adjusted for all other covariates in the table.

^bP-values are compared with the reference category.