Table 1.

Model variables and user-input simulation parameters

Parameter	Function	Default value
π	Minor allele frequency (MAF)	0.5
ψ	Uniformity of SNP effect sizes	50
α	Total additive genetic effect (produces A)	0.05
ε	Attraction of phenotype to static, additive environmental factors	0.05
δ	Attraction of phenotype to dynamic environmental factors	0.05
γ	Total GxE effect	0.05
ξ	GxE effect activation curve	10
υ	Probability per SNP of GxE	0.1
β	Attraction of dynamic environmental factors to phenotype	U (0.0175, 0.0325)
ζp	Rate of aging as damping of environment and phenotype	$-2\sqrt{ϵ}$
ζd	Rate of aging as damping of environment and phenotype	$-0.2\sqrt{\beta }$
N g	Number of gene SNPs	1000
Nd	Number of dynamic environmental factors	1
Ne	Number of static, additive environmental factors	1000
Variable	Description
gi	SNP effect i out of Ng total SNPs
P(t)	Phenotypic value at time t
dh(t)	Dynamic environment effect h out of Nd total at time t
lhi	Random nonlinear allelic effect
ej	Static, additive environment effect j out of Ne environmental factors
Index	Description
h	Dynamic Environment
i	SNP
j	Static, linear Environment
t	Time