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. 2022 Aug 30;54(8):1290–1305. doi: 10.1038/s12276-022-00837-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The flow chart showing the study design. b The bodyweight of the animals and c the tumor volume during the follow-up. d Representative images of tumors, e tumor weight, and f tumor volume at the endpoint of observation. g The expression of miR-375 and h mRNA level of PTPN4 were tested by qRT-PCR in endpoint tumor tissues. i Western blot showing the expression of p-STAT3, PTPN4, BCL2 and cleaved-PARP1 in tumor tissues. j IHC analysis of the expression of PTPN4 and Ki67 in the two groups.