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. 2022 Sep 2;12:14998. doi: 10.1038/s41598-022-18987-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The distribution of hubs, activated areas, and deactivated areas shows that anterior regions are more engaged in the diseased groups. (a) The frequency distribution across the 7-module parcellation. The left and right sides of each sub-plot denoted by a vertical black line represent the distribution across modules limited to the left and right hemispheres, respectively (b) The spatial distribution of the hub regions. The vertex size is proportional to the vertex strength. (c) The spatial distribution of vertices that are activated (denoted by $△$ ) and deactivated (denoted by $▽$ ) in the diseases. A vertex was called activated (deactivated) with respect to disease if the subtraction of its strength in the disease network from the CN network was significantly larger (smaller) than the similar value for other vertices. The vertex size is proportional to the value of this subtraction. Visualizations in (b) and (c) were created using Nilearn package.