Figure 7.
Mitochondrial STAT6 accumulation leads to tumorigenesis inhibition
In vivo results on xenograft mouse models.
(A–C) Parental or STAT6 KO-293T stable cell line (2 × 106 cells) was injected subcutaneously into the left or right flank of nude mice (n = 18).
(A) Representative images of xenograft tumor.
(B) Tumor growth curve was measured over time. Data are plotted as mean ± SEM with error bars by two-way repeated measures ANOVA. (∗∗∗∗p < 0.0001) (C) Weight of xenograft tumors. Data represent mean ± SD with error bar (n = 18). ∗∗p < 0.01 (D–H) STAT6 KO-293T, STAT6 WT, ΔSH2, and ΔMTS were inoculated subcutaneously into the left (STAT6 KO) or right (STAT6 WT, ΔSH2, or ΔMTS) flank of nude mice.
(D–F) Representative images of xenograft tumors.
(G) Tumor growth curve was measured. Data are plotted as mean ± SEM with error bars by two-way repeated measures ANOVA and Tukey’s post-hoc test. ∗∗∗∗p < 0.0001 (STAT6 WT or ΔSH2 vs STAT6 KO).
(H) Weight of xenograft tumors. Data represent mean ± S.D. with error bars by one-way ANOVA and Tukey’s post-hoc test. (STAT6 KO, n = 35; STAT6 WT, n = 12; ΔSH2, n = 10; ΔMTS, n = 13). ∗∗p < 0.01 (STAT6 WT or ΔSH2 vs STAT6 KO) and ∗∗∗p < 0.001 (STAT6 WT or ΔSH2 vs ΔMTS).