Table 1.
Demographic characteristics of the EPoS RNA-Seq Cohort
| Clinical features | Patients (n) | Values (mean ± SD and/or patients ‘n’) |
|---|---|---|
| Age (mean ± SD) | 206 | 54 (±11.87) |
| Sex | ||
| male | 206 | 123 |
| female | 83 | |
| BMI (mean ± SD) | 204 | 31.34 (±5.04) |
| T2DM | 206 | |
| no | 96 | |
| yes | 110 | |
| HBA1C (mmol/mol ± SD) | 135 | 48.06 (±14.54) |
| ALT (mean ± SD) | 204 | 67.12 (±41.61) |
| AST (mean ± SD) | 201 | 44.67 (±23.08) |
| Steatosis grade | 206 | |
| 0 | 0 | |
| 1 | 60 | |
| 2 | 73 | |
| 3 | 73 | |
| Ballooning | 206 | |
| 0 | 52 | |
| 1 | 98 | |
| 2 | 56 | |
| Kleiner lobular Inflammation |
206 | |
| 0 | 16 | |
| 1 | 95 | |
| 2 | 80 | |
| 3 | 15 | |
| SAF lobular inflammation | 206 | |
| 0 | 16 | |
| 1 | 140 | |
| 2 | 50 | |
| Brunt fibrosis stage | 206 | |
| 0 | 38 | |
| 1 | 47 | |
| 2 | 53 | |
| 3 | 54 | |
| 4 | 14 | |
| NASH | 206 | |
| no | 53 | |
| yes | 153 | |
| NAS score ≥ 4 | 206 | |
| no | 58 | |
| yes | 148 | |
| SAF activity score ≥ 2 | 206 | |
| no | 53 | |
| yes | 153 | |
| HSD17B13 rs72613567 (−/−T/TT) [unknown] | 188 | 120/61/7 [18] |
| PNPLA3 rs738409 (CC/GC/GG) | 206 | 75/89/42 |
| TM6SF2 rs58542926 (CC/CT/TT) | 206 | 156/48/2 |