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. 2022 Jul 31;3(9):100385. doi: 10.1016/j.jtocrr.2022.100385

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Brigatinib efficacy in patients with crizotinib-refractory ALK+ NSCLC in ALTA. (A) Kaplan-Maier estimates of IRC-assessed PFS in the ITT population. Of the 112 patients in arm A, 73 (65%) had an event; of the 110 patients in arm B, 62 (56%) had an event. (B) OS. Of the 112 patients in arm A, 64 (57%) died; of the 110 patients in arm B, 54 (49%) died. (C) Forest plot of subgroup analyses of investigator-assessed confirmed ORR. (D) Intracranial PFS in patients with any brain metastases (measurable or nonmeasurable) per the IRC at baseline. Of the 81 assessable patients in arm A, 43 (53%) had an event; of the 74 assessable patients in arm B, 35 (47%) had an event. Tick marks in Kaplan-Maier plots indicate censored data. ^a180 mg once daily with 7-day lead-in at 90 mg. ALK+, ALK rearrangement positive; CR, complete response; iPFS, intracranial progression-free survival; IRC, independent review committee; ITT, intention-to-treat; NR, not reached; ORR, objective response rate; OS, overall survival; PFS, progression-free survival; PR, partial response.