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. 2022 Sep 3;13:5190. doi: 10.1038/s41467-022-32814-y

Fig. 3. Interrupted time series analysis (ITSA) of the preterm birth rate across different type pregnancies in Wuhan, 2012–2020.

Fig. 3

a singleton births; b multiple births; c the result of ITSA across different type pregnancies. Dots indicate true monthly preterm birth rates and solid lines indicate the mean of estimated preterm birth rates per month by ITSA model, and red solid lines indicate the mean of estimated preterm birth rates per month assuming that COVID-19 mitigation measure had not occurred by ordinary least-squares regression with Newey-West standard errors. Baseline: from January 1, 2012 to January 31, 2020; Intervention stage: from February 1, 2020 to December 31, 2020. Intercept change: change in level compared with the previous stage; Slope change: change in trend compared with the previous stage, per month. CI: confidence interval; COVID-19: coronavirus disease 2019. The p values are two-sided.