Table 1.
Risk of adverse clinical events and relationship with ABC pathway in clinically complex, frail, multimorbid and polypharmacy patients (n=6091)
| Clinically complex N=4785 |
Frailty N=1175 |
Multimorbidity N=4535 |
Polypharmacy N=2934 |
|
|---|---|---|---|---|
| All-cause death | ||||
| ABC adherent, vs. non-adherent | 0.72 [0.58–0.91] | 0.63 [0.38–1.04] | 0.71 [0.57–0.89] | 0.86 [0.66–1.11] |
| 1 ABC criteria, vs. 0 | 0.53 [0.35–0.78] | 0.50 [0.32–0.79] | 0.51 [0.34–0.76] | 0.52 [0.29–0.95] |
| 2 ABC criteria, vs. 0 | 0.34 [0.23–0.50] | 0.37 [0.23–0.58] | 0.32 [0.21–0.47] | 0.39 [0.22–0.69] |
| 3 ABC criteria, vs. 0 | 0.29 [0.19–0.44] | 0.28 [0.15–0.53] | 0.27 [0.18–0.42] | 0.37 [0.20–0.68] |
| For each criteria | 0.69 [0.62–0.78] | 0.67 [0.56–0.80] | 0.68 [0.60–0.76] | 0.80 [0.68–0.93] |
| 2–3 ABC criteria, vs. 0–1 | 0.56 [0.47–0.68] | 0.61 [0.46–0.81] | 0.55 [0.45–0.66] | 0.68 [0.53–0.88] |
| MACE | ||||
| ABC adherent, vs. non-adherent | 0.68 [0.52–0.87] | 0.88 [0.54–1.42] | 0.69 [0.53–0.88] | 0.80 [0.60–1.06] |
| 1 ABC criteria, vs. 0 | 0.69 [0.42–1.12] | 0.57 [0.33–0.98] | 0.64 [0.39–1.06] | 0.63 [0.29–1.33] |
| 2 ABC criteria, vs. 0 | 0.45 [0.28–0.74] | 0.41 [0.23–0.71] | 0.44 [0.27–0.71] | 0.58 [0.28–1.20] |
| 3 ABC criteria, vs. 0 | 0.36 [0.21–0.60] | 0.44 [0.22–0.85] | 0.35 [0.21–0.58] | 0.48 [0.23–1.02] |
| For each criteria | 0.71 [0.62–0.81] | 0.75 [0.61–0.92] | 0.71 [0.63–0.82] | 0.85 [0.72–1.00] |
| 2–3 ABC criteria, vs. 0–1 | 0.59 [0.47–0.73] | 0.66 [0.48–0.91] | 0.60 [0.48–0.75] | 0.83 [0.61–1.12] |
| Composite outcome | ||||
| ABC adherent, vs. non-adherent | 0.70 [0.58–0.85] | 0.75 [0.50–1.12] | 0.70 [0.58–0.85] | 0.82 [0.66–1.03] |
| 1 ABC criteria, vs. 0 | 0.65 [0.45–0.95] | 0.62 [0.40–0.95] | 0.61 [0.42–0.90] | 0.58 [0.33–1.00] |
| 2 ABC criteria, vs. 0 | 0.43 [0.30–0.63] | 0.46 [0.30–0.70] | 0.41 [0.28–0.59] | 0.46 [0.27–0.78] |
| 3 ABC criteria, vs. 0 | 0.35 [0.24–0.52] | 0.41 [0.24–0.71] | 0.33 [0.22–0.49] | 0.41 [0.23–0.71] |
| For each criteria | 0.72 [0.65–0.79] | 0.74 [0.63–0.87] | 0.71 [0.64–0.79] | 0.81 [0.71–0.92] |
| 2–3 ABC criteria, vs. 0–1 | 0.59 [0.50–0.70] | 0.66 [0.52–0.85] | 0.59 [0.50–0.70] | 0.72 [0.57–0.90] |
Legend: HR [95%CI] adjusted for age, sex, type of AF, hypertension, diabetes, congestive heart failure, coronary artery disease, peripheral artery disease and previous thromboembolism