Fig. 2.

TRA expression mechanism by Fezf2 or Aire with Chd4 in mTECs in the thymus for immune homeostasis and surveillance: Super-enhancer mediated TRA expression by Aire (right), typical-enhancer mediated TRA expression by Fezf2 which forms NURD complex with Chd4 on the promoter regions (left). TRA-recognizing T cells differentiate into Treg cells or escape as autoreactive T cells from the thymus. Such T cells migrate to the secondary lymphoid organs and are distributed in specific peripheral tissues for immune homeostasis or surveillance