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. 2022 Sep 2;21:172. doi: 10.1186/s12933-022-01585-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Ratio to baseline at end-of-treatment for hsCRP by trial according to clinical cutoffs. Panel (a) shows SUSTAIN 3 data, panel (b) PIONEER 1 data, panel (c) PIONEER 2 data, and panel (d) PIONEER 5 data. ‘On-treatment without rescue medication’ data from the full analysis set. Ratios to baseline were analyzed using a mixed model for repeated measurements with treatment by hsCRP groups as categorical fixed effects and baseline hsCRP value (log-transformed) as covariate, all nested within visit, and an unstructured residual covariance matrix on log-transformed values. Clinical cut-offs used in this analysis were < 1.0, ≥ 1.0 to ≤ 3.0, and > 3.0 mg/L. CI confidence interval; ETR estimated treatment ratio; exenatide ER exenatide extended-release; hsCRP high-sensitivity C-reactive protein; N number of subjects with available hsCRP data; s.c. subcutaneous

Fig. 2 — Ratio to baseline at end-of-treatment for hsCRP by trial according to clinical cutoffs. Panel (a) shows SUSTAIN 3 data, panel (b) PIONEER 1 data, panel (c) PIONEER 2 data, and panel (d) PIONEER 5 data. ‘On-treatment without rescue medication’ data from the full analysis set. Ratios to baseline were analyzed using a mixed model for repeated measurements with treatment by hsCRP groups as categorical fixed effects and baseline hsCRP value (log-transformed) as covariate, all nested within visit, and an unstructured residual covariance matrix on log-transformed values. Clinical cut-offs used in this analysis were < 1.0, ≥ 1.0 to ≤ 3.0, and > 3.0 mg/L. CI confidence interval; ETR estimated treatment ratio; exenatide ER exenatide extended-release; hsCRP high-sensitivity C-reactive protein; N number of subjects with available hsCRP data; s.c. subcutaneous