Table 1.
Characteristics of Included Studies
| Authors Year | Methods | Intervention | Language | Age (Years) | Gender (Male/Total) | APACHE II Score | PaCO2, mmHg | Outcomes | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HFNC | NIV | HFNC | NIV | HFNC | NIV | HFNC | NIV | |||||
| Zhang 201817 | RCT | HFNC vs NIV | Chinese | 64.5±5.3 | 66.1±6.6 | 18/21 | 20/24 | 16.3±1.4 | 16.7±1.6 | 42.9±7.7 | 43.3±8.1 | ①②③④⑤⑥ |
| Yu 201918 | RCT | HFNC vs NIV | Chinese | 62.4±10.1 | 63.5±11.2 | 24/36 | 21/36 | 28.6±2.8 | 28.5±3.4 | 73.56±6.9 | 73.50±6.23 | ①②③④⑤⑥⑦⑧⑨ |
| Jing 201919 | RCT | HFNC vs NIV | English | 77.4±6.8 | 73.9 ±6.9 | NA | NA | 11.8±3.1 | 10.4±2.5 | 53.2±6.7 | 53.7 ±8.6 | ①②③④⑤⑥⑦⑧⑨ |
| Yang 202020 | RCT | HFNC vs NIV | Chinese | 69±9 | 67±9 | 25/40 | 20/33 | 12.3±1.9 | 12.1±1.8 | 55±9 | 56±8 | ①②⑤ |
| Thille 202121 | RCT | HFNC vs NIV | English | 66±9 | 66±9 | 48/64 | 61/86 | NA | NA | 44±9 | 43±8 | ①②④ |
| Xu 202122 | RCT | HFNC vs NIV | English | 69.22 ±6.13 | 68.39 ±5.22 | NA | NA | NA | NA | NA | NA | ①③⑤⑥⑦ |
| Fang 202123 | RCT | HFNC vs NIV | Chinese | 67.9±6.9 | 72.3±7.8 | 14/20 | 11/24 | 14.3±3.8 | 15.0±2.9 | 39.4±6.5 | 40.0±8.9 | ①②③④⑤⑦⑧⑨ |
| Tan 202024 | RCT | HFNC vs NIV | English | 68.4± 9.3 | 71.4± 7.8 | 27/44 | 23/42 | 14(11–18.8) | 13(10.8–16) | 50.5(48–57.8) | 53(48.8–61.3) | ①②③④⑤⑥⑦⑧⑨ |
Notes: Outcomes:①reintubation rates②mortality③complication rates④ length of ICU stay ⑤PaCO2 ⑥ PaO2/FiO2 ⑦RR ⑧ HR ⑨PH.
Abbreviations: RCT, randomized controlled trial; HFNC, high-flow nasal cannula; NIV, non-invasive ventilation; NA, not applicable.