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. 2022 Jul 28;149(15):dev200510. doi: 10.1242/dev.200510

Fig. 3.

Fig. 3.

‘Immobilization by sequestration’ model with intermediary. (A) Cartoon of the model, same as Fig. 2H except that WOX5 activates a diffusible intermediary Z, which in turn activates BRAVO. (B) Cartoon of the model in the one-dimensional spatial framework. WOX5 self-repression is not represented for clarity. (C) Stationary activity profiles pB and pW (inset) in WT (continuous lines) and in the bravo mutant (dashed lines) for equal WOX5 and Z diffusion coefficients (DW=DZ=2). (D) Stationary pB profiles in the WT (continuous) and in bravo mutant (dashed) for non-mobile Z (violet) and for stronger mobile Z (pink). (E,F) Parameter domains (yellow) compatible with experimental observations for (E) WOX5 diffusion coefficient DW and binding strength λ, and (F) WOX5 diffusion coefficient DW and Z diffusion coefficient DZ parameter spaces. Conditions for RW are satisfied in all the depicted spaces (indicated by the absence of a dot-dashed line). Fig. S4 depicts the values of the observables. Red stars mark the parameter values used in C. Production functions are nonlinear. Parameter values are given in Table S1. a.u., arbitrary units.