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. Author manuscript; available in PMC: 2022 Sep 3.
Published in final edited form as: Biochem J. 2016 Sep 13;473(22):4159–4172. doi: 10.1042/BCJ20160620

Figure 3. Nebivolol modifies the gating of single RyR2 channels.

Figure 3.

Single RyR2 channels from native rat SR microsomes were fused into planar lipid bilayers and recorded in the absence (control) (a) or 10 minutes after the addition of nebivolol (30μM) (b). Recordings were made at +40 mV. Open events are upward from the marked zero current level (short bars). Opening probability (c), mean open time (d), and mean closed time (e) are shown in control, 0–3 or 3–10 minutes after nebivolol (30μM) addition. Data shown are means ± SEM (n=6–11; *P < 0.01; **P < 0.05 vs control).